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    MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [ Bos taurus (domestic cattle) ]

    Gene ID: 507991, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MTRRprovided by VGNC
    Official Full Name
    5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:58606
    See related
    BGD:BT16201; EnsemblRapid:ENSBTAG00070019217
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MSR
    Orthologs
    human mouse all
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    Genomic context

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    See MTRR in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (65310105..65343079, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443048 Neighboring gene U6 spliceosomal RNA Neighboring gene FAST kinase domains 3 Neighboring gene cilia and flagella associated protein 90

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables [methionine synthase] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homocysteine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine synthase reductase
    Names
    aqCbl reductase
    aquacobalamin reductase
    NP_001025470.1
    XP_005221697.1
    XP_005221698.1
    XP_024837015.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030299.1 → NP_001025470.1  methionine synthase reductase

      See identical proteins and their annotated locations for NP_001025470.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ084520
      UniProtKB/Swiss-Prot
      Q4JIJ2
      UniProtKB/TrEMBL
      A0AAA9TIM9
      Related
      ENSBTAP00070026109.1, ENSBTAT00070043396.1
      Conserved Domains (3) summary
      cd06203
      Location:275 → 695
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      COG0369
      Location:5 → 695
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:6 → 142
      Flavodoxin_1; Flavodoxin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65310105..65343079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221641.5 → XP_005221698.1  methionine synthase reductase isoform X2

      UniProtKB/TrEMBL
      A0AAA9TIM9, A0AAA9TQV4
      Related
      ENSBTAP00070026125.1, ENSBTAT00070043416.1
      Conserved Domains (3) summary
      cd06203
      Location:231 → 651
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      COG0369
      Location:5 → 651
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:6 → 88
      Flavodoxin_1; Flavodoxin

    2. XM_005221640.5 → XP_005221697.1  methionine synthase reductase isoform X1

      See identical proteins and their annotated locations for XP_005221697.1

      UniProtKB/TrEMBL
      A0AAA9TIM9, F1MGP5
      Conserved Domains (2) summary
      cd06203
      Location:275 → 695
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6 → 142
      Flavodoxin_1; Flavodoxin

    3. XM_024981247.2 → XP_024837015.1  methionine synthase reductase isoform X1

      UniProtKB/TrEMBL
      A0AAA9TIM9, F1MGP5
      Conserved Domains (2) summary
      cd06203
      Location:275 → 695
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6 → 142
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4JIJ2.1 GenPept UniProtKB/Swiss-Prot:Q4JIJ2

    Gene LinkOut

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