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    NUDT12 nudix hydrolase 12 [ Bos taurus (domestic cattle) ]

    Gene ID: 617720, updated on 30-Jan-2025

    Summary

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    Official Symbol
    NUDT12provided by VGNC
    Official Full Name
    nudix hydrolase 12provided by VGNC
    Primary source
    VGNC:VGNC:32326
    See related
    EnsemblRapid:ENSBTAG00070000447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NUDT12 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (102607081..102621172, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101906022 Neighboring gene uncharacterized LOC132345850 Neighboring gene uncharacterized LOC101905838 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC137455

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in NADH metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in NADP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD-capped RNA hydrolase NUDT12
    Names
    NADH pyrophosphatase NUDT12
    deNADding enzyme NUDT12
    nucleoside diphosphate-linked moiety X motif 12
    nudix (nucleoside diphosphate linked moiety X)-type motif 12
    nudix motif 12
    nudix-type motif 12
    peroxisomal NADH pyrophosphatase NUDT12
    NP_001040073.1
    XP_005209829.1
    XP_005209830.1
    XP_005209831.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046608.2 → NP_001040073.1  NAD-capped RNA hydrolase NUDT12

      See identical proteins and their annotated locations for NP_001040073.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114173
      UniProtKB/Swiss-Prot
      Q29RH3
      Conserved Domains (4) summary
      COG2816
      Location:108 → 437
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd03429
      Location:305 → 439
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:130 → 259
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:261 → 284
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      102607081..102621172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005209773.5 → XP_005209830.1  NAD-capped RNA hydrolase NUDT12 isoform X1

      See identical proteins and their annotated locations for XP_005209830.1

      UniProtKB/TrEMBL
      A0AAF6ZDK8
      Conserved Domains (7) summary
      COG2816
      Location:126 → 455
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd00204
      Location:16 → 98
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03429
      Location:323 → 457
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:148 → 277
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:279 → 302
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
      pfam13857
      Location:31 → 86
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:16 → 43
      ANK; ANK repeat [structural motif]

    2. XM_005209772.5 → XP_005209829.1  NAD-capped RNA hydrolase NUDT12 isoform X1

      See identical proteins and their annotated locations for XP_005209829.1

      UniProtKB/TrEMBL
      A0AAF6ZDK8
      Related
      ENSBTAP00070000667.1, ENSBTAT00070000981.1
      Conserved Domains (7) summary
      COG2816
      Location:126 → 455
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd00204
      Location:16 → 98
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03429
      Location:323 → 457
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:148 → 277
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:279 → 302
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
      pfam13857
      Location:31 → 86
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:16 → 43
      ANK; ANK repeat [structural motif]

    3. XM_005209774.5 → XP_005209831.1  NAD-capped RNA hydrolase NUDT12 isoform X1

      See identical proteins and their annotated locations for XP_005209831.1

      UniProtKB/TrEMBL
      A0AAF6ZDK8
      Related
      ENSBTAP00070000672.1, ENSBTAT00070000986.1
      Conserved Domains (7) summary
      COG2816
      Location:126 → 455
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd00204
      Location:16 → 98
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03429
      Location:323 → 457
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:148 → 277
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:279 → 302
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
      pfam13857
      Location:31 → 86
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:16 → 43
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29RH3.1 GenPept UniProtKB/Swiss-Prot:Q29RH3

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