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    DNPEP aspartyl aminopeptidase [ Bos taurus (domestic cattle) ]

    Gene ID: 506882, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DNPEPprovided by VGNC
    Official Full Name
    aspartyl aminopeptidaseprovided by VGNC
    Primary source
    VGNC:VGNC:28148
    See related
    BGD:BT30282; Ensembl:ENSBTAG00000021514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DNPEP in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (107307882..107331759, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene regulated endocrine specific protein 18 Neighboring gene desmin Neighboring gene striated muscle enriched protein kinase Neighboring gene SPEG neighbor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. Chen Y, et al. J Biol Chem, 2012 Apr 13. PMID 22356908, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNPEP assembles into a functionally relevant tetrahedral complex that restricts access of peptide substrates to the active site.
      Title: Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128181

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aspartyl aminopeptidase
    NP_001039417.1
    XP_005202875.1
    XP_024855605.1
    XP_024855607.1
    XP_024855612.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045952.1 → NP_001039417.1  aspartyl aminopeptidase

      See identical proteins and their annotated locations for NP_001039417.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105402
      UniProtKB/Swiss-Prot
      Q2HJH1
      UniProtKB/TrEMBL
      A0A3Q1M7H7
      Related
      ENSBTAP00000078667.1, ENSBTAT00000090699.1
      Conserved Domains (1) summary
      cd05658
      Location:14 → 459
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      107307882..107331759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999844.2 → XP_024855612.1  aspartyl aminopeptidase isoform X4

      UniProtKB/Swiss-Prot
      Q2HJH1
      UniProtKB/TrEMBL
      A0A3Q1M7H7
      Conserved Domains (1) summary
      cd05658
      Location:14 → 459
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase

    2. XM_024999837.2 → XP_024855605.1  aspartyl aminopeptidase isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M7H7
      Conserved Domains (1) summary
      cd05658
      Location:52 → 497
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase

    3. XM_024999839.2 → XP_024855607.1  aspartyl aminopeptidase isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M7H7
      Conserved Domains (1) summary
      cd05658
      Location:43 → 488
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase

    4. XM_005202818.4 → XP_005202875.1  aspartyl aminopeptidase isoform X3

      See identical proteins and their annotated locations for XP_005202875.1

      UniProtKB/TrEMBL
      A0A3Q1M7H7
      Related
      ENSBTAP00000102691.1, ENSBTAT00000121374.1
      Conserved Domains (1) summary
      cd05658
      Location:18 → 463
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2HJH1.1 GenPept UniProtKB/Swiss-Prot:Q2HJH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.