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    ELOVL6 ELOVL fatty acid elongase 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 533333, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ELOVL6provided by VGNC
    Official Full Name
    ELOVL fatty acid elongase 6provided by VGNC
    Primary source
    VGNC:VGNC:28452
    See related
    BGD:BT17431; Ensembl:ENSBTAG00000010564
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ELOVL6 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (15228001..15362448)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene epidermal growth factor Neighboring gene large ribosomal subunit protein eL30-like Neighboring gene 40S ribosomal protein S26 pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Effect of ELOVL6 on the lipid metabolism of bovine adipocytes. Junjvlieke Z, et al. Genomics, 2020 May. PMID 31901374
    2. Transcriptional regulation of bovine elongation of very long chain fatty acids protein 6 in lipid metabolism and adipocyte proliferation. Junjvlieke Z, et al. J Cell Biochem, 2019 Aug. PMID 30945346
    3. Tissue expression profiles and transcriptional regulation of elongase of very long chain fatty acid 6 in bovine mammary epithelial cells. Chen S, et al. PLoS One, 2017. PMID 28414811, Free PMC Article
    4. Elongase of very long chain fatty acids 6 (ELOVL6) promotes lipid synthesis in buffalo mammary epithelial cells. Fan X, et al. J Anim Physiol Anim Nutr (Berl), 2022 Jan. PMID 33742447
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of ELOVL6 on the lipid metabolism of bovine adipocytes.
      Title: Effect of ELOVL6 on the lipid metabolism of bovine adipocytes.
    2. Transcriptional regulation of bovine elongation of very long chain fatty acids protein 6 in lipid metabolism and adipocyte proliferation.
      Title: Transcriptional regulation of bovine elongation of very long chain fatty acids protein 6 in lipid metabolism and adipocyte proliferation.
    3. ELOVL6 is expressed ubiquitously in mammary epithelial cells and is activated by SREBF1 and SP1, via two binding sites present in the ELOVL6 promoter region between -130 bp to -41bp.
      Title: Tissue expression profiles and transcriptional regulation of elongase of very long chain fatty acid 6 in bovine mammary epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139109

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid elongation, monounsaturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fatty acid elongation, polyunsaturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fatty acid elongation, saturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in very long-chain fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    very long chain fatty acid elongase 6
    Names
    ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
    NP_001095625.1
    XP_015326989.1
    XP_059743545.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102155.1 → NP_001095625.1  very long chain fatty acid elongase 6

      See identical proteins and their annotated locations for NP_001095625.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148954
      UniProtKB/TrEMBL
      A0AAF6DMC9, A6QNQ7, F1MN24
      Related
      ENSBTAP00070036087.1, ENSBTAT00070060689.1
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15228001..15362448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015471503.3 → XP_015326989.1  very long chain fatty acid elongase 6 isoform X1

      UniProtKB/TrEMBL
      A0AAF6DMC9, A6QNQ7, F1MN24
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family

    2. XM_059887562.1 → XP_059743545.1  very long chain fatty acid elongase 6 isoform X2

      UniProtKB/TrEMBL
      A0AAF6DMC9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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