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    ACO2 aconitase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 280976, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ACO2provided by VGNC
    Official Full Name
    aconitase 2provided by VGNC
    Primary source
    VGNC:VGNC:25546
    See related
    BGD:BT23912; Ensembl:ENSBTAG00000006429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ACO2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (112568137..112617201)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene transducer of ERBB2, 2 Neighboring gene PHD finger protein 5A Neighboring gene uncharacterized LOC112446877 Neighboring gene RNA polymerase III subunit H Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene cold shock domain containing C2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification of the reactive sulfhydryl and sequences of cysteinyl-tryptic peptides from beef heart aconitase. Plank DW, et al. J Biol Chem, 1988 Jun 15. PMID 3372519
    2. Cysteine labeling studies of beef heart aconitase containing a 4Fe, a cubane 3Fe, or a linear 3Fe cluster. Plank DW, et al. J Biol Chem, 1989 Dec 5. PMID 2511202
    3. Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Lauble H, et al. Biochemistry, 1992 Mar 17. PMID 1547214
    4. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Kennedy MC, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1334546, Free PMC Article
    5. Isolation of coding sequences from bovine cosmids by means of exon trapping. Comincini S, et al. Mamm Genome, 1997 Jul. PMID 9195992

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aconitate hydratase, mitochondrial
    Names
    aconitase 2, mitochondrial
    citrate hydro-lyase
    NP_776402.1
    XP_059742072.1
    XP_059742073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173977.3 → NP_776402.1  aconitate hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_776402.1

      Status: PROVISIONAL

      Source sequence(s)
      Z49931
      UniProtKB/TrEMBL
      A0AAF6YQ44
      Related
      ENSBTAP00000078293.1, ENSBTAT00000126438.1
      Conserved Domains (3) summary
      cd01584
      Location:95 → 505
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:587 → 735
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:45 → 775
      aconitase_mito; aconitate hydratase, mitochondrial

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      112568137..112617201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886089.1 → XP_059742072.1  aconitate hydratase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q1P9Q3

    2. XM_059886090.1 → XP_059742073.1  aconitate hydratase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q1P9Q3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20004.4 GenPept UniProtKB/Swiss-Prot:P20004

    Gene LinkOut

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