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    MKNK1 MAPK interacting serine/threonine kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 525647, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MKNK1provided by VGNC
    Official Full Name
    MAPK interacting serine/threonine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:31491
    See related
    BGD:BT28534; Ensembl:ENSBTAG00000019933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MKNK1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (99527397..99573217)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene small nucleolar RNA U2-30 Neighboring gene MOB kinase activator 3C Neighboring gene kinocilin Neighboring gene uncharacterized LOC132344919 Neighboring gene transmembrane protein 275

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC133983

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 1
    Names
    MAP kinase interacting serine/threonine kinase 1
    MAP kinase signal-integrating kinase 1
    MAPK signal-integrating kinase 1
    mnk1
    NP_001030435.1
    XP_005204810.1
    XP_059740571.1
    XP_059740572.1
    XP_059740573.1
    XP_059740574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035358.1 → NP_001030435.1  MAP kinase-interacting serine/threonine-protein kinase 1

      See identical proteins and their annotated locations for NP_001030435.1

      Status: PROVISIONAL

      Source sequence(s)
      BT021703
      UniProtKB/Swiss-Prot
      Q2T9R8, Q58D94
      Conserved Domains (2) summary
      smart00220
      Location:41 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      99527397..99573217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059884588.1 → XP_059740571.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2T9R8, Q58D94
      UniProtKB/TrEMBL
      A0AAA9SGM8

    2. XM_005204753.5 → XP_005204810.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2T9R8, Q58D94
      UniProtKB/TrEMBL
      A0AAA9SGM8
      Related
      ENSBTAP00000084508.1, ENSBTAT00000113430.1
      Conserved Domains (2) summary
      smart00220
      Location:47 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    3. XM_059884591.1 → XP_059740574.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      Related
      ENSBTAP00000026554.7, ENSBTAT00000026554.7

    4. XM_059884590.1 → XP_059740573.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q2T9R8, Q58D94

    5. XM_059884589.1 → XP_059740572.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      F1N1A7
      Related
      ENSBTAP00000026556.5, ENSBTAT00000026556.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58D94.2 GenPept UniProtKB/Swiss-Prot:Q58D94

    Gene LinkOut

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    Research Materials