THOP1 thimet oligopeptidase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: THOP1provided by VGNC
Official Full Name: thimet oligopeptidase 1provided by VGNC
Primary source: VGNC:VGNC:35843
See related: BGD:BT11734; EnsemblRapid:ENSBTAG00070002291
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (20887196..20901065, complement)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity
Title: Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels.
Cyclic strain putatively regulates both the mRNA expression and enzymatic function of EP24.15 and EP24.16.
Title: Regulation of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: role of Gi protein signaling.

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General gene information

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Markers

MARC_2537-2538:966894345:1 (e-PCR)
- UniSTS:268906

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptide metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thimet oligopeptidase

Names: endopeptidase EC3.4.24.15

NP_001029163.2

EC 3.4.24.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033991.3 → NP_001029163.2 thimet oligopeptidase

See identical proteins and their annotated locations for NP_001029163.2

Status: PROVISIONAL

Source sequence(s)

BC149983

UniProtKB/Swiss-Prot

A6QQT3, Q1JPJ8

UniProtKB/TrEMBL

A0A140T8A4

Related

ENSBTAP00070003011.1, ENSBTAT00070005292.1

Conserved Domains (2) summary

cd06455
Location:35 → 675

M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin

COG0339
Location:37 → 679

Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]