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    MAPK12 mitogen-activated protein kinase 12 [ Bos taurus (domestic cattle) ]

    Gene ID: 512943, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MAPK12provided by VGNC
    Official Full Name
    mitogen-activated protein kinase 12provided by VGNC
    Primary source
    VGNC:VGNC:31215
    See related
    BGD:BT16381; EnsemblRapid:ENSBTAG00070007671
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MAPK12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (119618818..119626764, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex associated protein 6 Neighboring gene histone deacetylase 10 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC160082

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 12
    NP_001092423.1
    XP_005207572.1
    XP_059742309.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098953.1 → NP_001092423.1  mitogen-activated protein kinase 12

      See identical proteins and their annotated locations for NP_001092423.1

      Status: PROVISIONAL

      Source sequence(s)
      BC142157
      UniProtKB/TrEMBL
      A0A3Q1MF91, A5PJL3
      Related
      ENSBTAP00070010059.1, ENSBTAT00070017319.1
      Conserved Domains (2) summary
      cd07880
      Location:11 → 353
      STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)
      smart00220
      Location:27 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      119618818..119626764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886326.1 → XP_059742309.1  mitogen-activated protein kinase 12 isoform X2

    2. XM_005207515.5 → XP_005207572.1  mitogen-activated protein kinase 12 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SP07
      Related
      ENSBTAP00070010044.1, ENSBTAT00070017296.1
      Conserved Domains (2) summary
      smart00220
      Location:27 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:11 → 342
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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