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    NEFM neurofilament medium chain [ Bos taurus (domestic cattle) ]

    Gene ID: 281347, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NEFMprovided by VGNC
    Official Full Name
    neurofilament medium chainprovided by VGNC
    Primary source
    VGNC:VGNC:31987
    See related
    BGD:BT17405; Ensembl:ENSBTAG00000039530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NEF3; NF-M
    Orthologs
    human mouse all
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    Genomic context

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    See NEFM in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (72181225..72186703)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene ADAM-like, decysin 1 Neighboring gene ADAM metallopeptidase domain 7 Neighboring gene neurofilament light chain Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Characterization of the bovine neurofilament NF-M protein and cDNA sequence, and identification of in vitro and in vivo calpain cleavage sites. Shaw G, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530438
    2. Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. Trimpin S, et al. Biochemistry, 2004 Feb 24. PMID 14967049
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables structural constituent of postsynaptic intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neurofilament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neurofilament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurofilament medium polypeptide
    Names
    160 kDa neurofilament protein
    major neuronal intermediate filament subunit
    neurofilament 3
    neurofilament M subunit
    neurofilament triplet M protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244145.1 → NP_001231074.1  neurofilament medium polypeptide

      See identical proteins and their annotated locations for NP_001231074.1

      Status: VALIDATED

      Source sequence(s)
      BC151624, DV831196, DV839158, EV613901
      UniProtKB/TrEMBL
      F1MDZ2, F6PP75
      Related
      ENSBTAP00000036438.5, ENSBTAT00000036581.5
      Conserved Domains (4) summary
      pfam00038
      Location:100 → 411
      Filament; Intermediate filament protein
      pfam04732
      Location:10 → 74
      Filament_head; Intermediate filament head (DNA binding) region
      pfam07382
      Location:602 → 699
      HC2; Histone H1-like nucleoprotein HC2
      pfam13863
      Location:122 → 228
      DUF4200; Domain of unknown function (DUF4200)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      72181225..72186703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010808063.3 → XP_010806365.2  neurofilament medium polypeptide isoform X1

      Conserved Domains (2) summary
      pfam00038
      Location:1 → 35
      Filament; Intermediate filament protein
      cl27975
      Location:245 → 332
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77788.3 GenPept UniProtKB/Swiss-Prot:O77788

    Gene LinkOut

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