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    PPARD peroxisome proliferator activated receptor delta [ Bos taurus (domestic cattle) ]

    Gene ID: 353106, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PPARDprovided by VGNC
    Official Full Name
    peroxisome proliferator activated receptor deltaprovided by VGNC
    Primary source
    VGNC:VGNC:33182
    See related
    BGD:BT10525; Ensembl:ENSBTAG00000017542
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PPAR-beta
    Orthologs
    human mouse all
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    Genomic context

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    See PPARD in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (9304277..9389930)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 76 Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene FA complementation group E Neighboring gene ribosomal protein L10a

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum. Sakumoto R, et al. J Reprod Dev, 2020 Jun 12. PMID 32037375, Free PMC Article
    2. Carnitine transporter OCTN2 and carnitine uptake in bovine kidney cells is regulated by peroxisome proliferator-activated receptor β/δ. Zhou X, et al. Acta Vet Scand, 2014 Apr 9. PMID 24716857, Free PMC Article
    3. The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos. Idrees M, et al. Int J Mol Sci, 2019 Dec 2. PMID 31810173, Free PMC Article
    4. Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus. Sheldrick EL, et al. Biochem J, 2007 Aug 15. PMID 17516915, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum.
      Title: Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum.
    2. GW501516-activated PPARd maintained the correlation between lipolysis and lipogenesis by enhancing PEPCK and CPT1 to improve bovine embryo quality.
      Title: The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.
    3. Gene expression of the carnitine transporter OCTN2 and carnitine transport are regulated by PPARbeta/delta in bovine cells.
      Title: Carnitine transporter OCTN2 and carnitine uptake in bovine kidney cells is regulated by peroxisome proliferator-activated receptor β/δ.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cholesterol storage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor delta
    Names
    peroxisome proliferative activated receptor, delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083636.1 → NP_001077105.1  peroxisome proliferator-activated receptor delta

      See identical proteins and their annotated locations for NP_001077105.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134636
      UniProtKB/TrEMBL
      A4IFL4, Q9N128
      Conserved Domains (2) summary
      cd06932
      Location:173 → 440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73 → 156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9304277..9389930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880228.1 → XP_059736211.1  peroxisome proliferator-activated receptor delta isoform X5

      UniProtKB/TrEMBL
      A0AAA9T3S0

    2. XM_059880230.1 → XP_059736213.1  peroxisome proliferator-activated receptor delta isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LKP0, A0AAA9T3S0

    3. XM_024983411.2 → XP_024839179.1  peroxisome proliferator-activated receptor delta isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LKP0, A0AAA9T3S0
      Conserved Domains (2) summary
      cd06932
      Location:135 → 402
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:57 → 118
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    4. XM_024983407.2 → XP_024839175.1  peroxisome proliferator-activated receptor delta isoform X3

      Conserved Domains (2) summary
      cd06932
      Location:183 → 450
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:105 → 166
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    5. XM_059880225.1 → XP_059736208.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LMI3, Q9N128

    6. XM_059880226.1 → XP_059736209.1  peroxisome proliferator-activated receptor delta isoform X2

      UniProtKB/TrEMBL
      Q9N128

    7. XM_059880227.1 → XP_059736210.1  peroxisome proliferator-activated receptor delta isoform X4

      UniProtKB/TrEMBL
      A0AAA9T683, Q9N128
      Related
      ENSBTAP00070013130.1, ENSBTAT00070022301.1
    Nucleotide Protein Strain
    Heading Accession and Version

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