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    NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 [ Bos taurus (domestic cattle) ]

    Gene ID: 288380, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NDUFS1provided by VGNC
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S1provided by VGNC
    Primary source
    VGNC:VGNC:56131
    See related
    BGD:BT20795; Ensembl:ENSBTAG00000021976
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NDUFS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (94459779..94489927, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D Neighboring gene translation initiation factor IF-2 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene small nucleolar RNA SNORD51 Neighboring gene small nucleolar RNA SNORA41 Neighboring gene eukaryotic translation elongation factor 1 beta 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors. Shinzawa-Itoh K, et al. Biochemistry, 2010 Jan 26. PMID 19961238
    2. Mitochondrial NADH:ubiquinone reductase: complementary DNA sequence of the import precursor of the bovine 75-kDa subunit. Runswick MJ, et al. Biochemistry, 1989 Nov 28. PMID 2514801
    3. Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I). Ohnishi ST, et al. Biochim Biophys Acta, 2010 Dec. PMID 20599678, Free PMC Article
    4. New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals. Ohnishi ST, et al. Biochim Biophys Acta, 2010 Dec. PMID 20513438
    5. Architecture of mammalian respiratory complex I. Vinothkumar KR, et al. Nature, 2014 Nov 6. PMID 25209663, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that during NADH-ubiquinone oxidoreductase (Complex I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ.
      Title: New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals.
    2. Data suggest that Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex I).
      Title: Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I).
    3. Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors
      Title: Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140590

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    Names
    CI-75kD
    NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
    complex I-75kD
    NP_777245.1
    XP_005202770.1
    XP_024854963.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174820.4 → NP_777245.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_777245.1

      Status: PROVISIONAL

      Source sequence(s)
      BC120069
      UniProtKB/Swiss-Prot
      P15690, Q0VCP7
      UniProtKB/TrEMBL
      A0AAA9TSL9
      Related
      ENSBTAP00000029301.3, ENSBTAT00000029301.4
      Conserved Domains (1) summary
      cl26508
      Location:31 → 722
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      94459779..94489927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202713.5 → XP_005202770.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005202770.1

      UniProtKB/Swiss-Prot
      P15690, Q0VCP7
      UniProtKB/TrEMBL
      A0AAA9TSL9
      Conserved Domains (1) summary
      cl26508
      Location:31 → 722
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region

    2. XM_024999195.2 → XP_024854963.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P15690, Q0VCP7
      UniProtKB/TrEMBL
      A0AAA9TSL9
      Conserved Domains (1) summary
      cl26508
      Location:31 → 722
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15690.1 GenPept UniProtKB/Swiss-Prot:P15690

    Gene LinkOut

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