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    RORA RAR related orphan receptor A [ Bos taurus (domestic cattle) ]

    Gene ID: 535597, updated on 1-Jan-2025

    Summary

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    Official Symbol
    RORAprovided by VGNC
    Official Full Name
    RAR related orphan receptor Aprovided by VGNC
    Primary source
    VGNC:VGNC:34088
    See related
    Ensembl:ENSBTAG00000015904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See RORA in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (48892424..49702373)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346369 Neighboring gene uncharacterized LOC132346370 Neighboring gene uncharacterized LOC104973154 Neighboring gene uncharacterized LOC104973153 Neighboring gene uncharacterized LOC101902861 Neighboring gene interactor of little elongation complex ELL subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxysterol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor ROR-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192861.1 → NP_001179790.1  nuclear receptor ROR-alpha

      See identical proteins and their annotated locations for NP_001179790.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      F1N7R0
      Related
      ENSBTAP00000021144.6, ENSBTAT00000021144.7
      Conserved Domains (2) summary
      cd06939
      Location:272 → 511
      NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
      cd06968
      Location:66 → 160
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48892424..49702373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059890518.1 → XP_059746501.1  nuclear receptor ROR-alpha isoform X1

      UniProtKB/TrEMBL
      F1N7R0

    2. XM_059890517.1 → XP_059746500.1  nuclear receptor ROR-alpha isoform X1

      UniProtKB/TrEMBL
      F1N7R0

    3. XM_059890519.1 → XP_059746502.1  nuclear receptor ROR-alpha isoform X2

      UniProtKB/TrEMBL
      F1N7R0

    4. XM_059890521.1 → XP_059746504.1  nuclear receptor ROR-alpha isoform X3

      UniProtKB/TrEMBL
      F1N7R0

    5. XM_059890520.1 → XP_059746503.1  nuclear receptor ROR-alpha isoform X3

      UniProtKB/TrEMBL
      F1N7R0
      Related
      ENSBTAP00000069722.1, ENSBTAT00000067938.2
    Nucleotide Protein Strain
    Heading Accession and Version

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