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    ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 533823, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ARHGEF6provided by VGNC
    Official Full Name
    Rac/Cdc42 guanine nucleotide exchange factor 6provided by VGNC
    Primary source
    VGNC:VGNC:26120
    See related
    BGD:BT28387; EnsemblRapid:ENSBTAG00070034921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See ARHGEF6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (20278167..20394964, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene transcription cofactor vestigial-like protein 1 Neighboring gene CD40 ligand Neighboring gene RNA-binding motif protein, X chromosome-like Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene microRNA mir-2484

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 6
    Names
    Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193000.1 → NP_001179929.1  rho guanine nucleotide exchange factor 6

      See identical proteins and their annotated locations for NP_001179929.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000030
      UniProtKB/TrEMBL
      E1BIM5
      Related
      ENSBTAP00070047815.1, ENSBTAT00070078462.1
      Conserved Domains (7) summary
      cd12060
      Location:162 → 219
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:242 → 419
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:450 → 547
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:573 → 678
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:681 → 767
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:115 → 160
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21265
      Location:1 → 117
      CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20278167..20394964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024988103.2 → XP_024843871.1  rho guanine nucleotide exchange factor 6 isoform X2

      Conserved Domains (7) summary
      cd12060
      Location:186 → 243
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 571
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:702 → 788
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:602 → 699
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    2. XM_024988102.2 → XP_024843870.1  rho guanine nucleotide exchange factor 6 isoform X1

      Conserved Domains (7) summary
      cd12060
      Location:186 → 243
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 571
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:709 → 795
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:602 → 706
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    3. XM_005227552.5 → XP_005227609.1  rho guanine nucleotide exchange factor 6 isoform X4

      See identical proteins and their annotated locations for XP_005227609.1

      Conserved Domains (7) summary
      cd12060
      Location:186 → 243
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 571
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:656 → 742
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:596 → 653
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    4. XM_005227551.5 → XP_005227608.1  rho guanine nucleotide exchange factor 6 isoform X3

      See identical proteins and their annotated locations for XP_005227608.1

      Conserved Domains (7) summary
      cd12060
      Location:186 → 243
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 571
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:663 → 749
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:593 → 660
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    5. XM_059883471.1 → XP_059739454.1  rho guanine nucleotide exchange factor 6 isoform X5

      Related
      ENSBTAP00070047803.1, ENSBTAT00070078431.1

    6. XM_059883474.1 → XP_059739457.1  rho guanine nucleotide exchange factor 6 isoform X7

    7. XM_059883476.1 → XP_059739459.1  rho guanine nucleotide exchange factor 6 isoform X6

    8. XM_024988105.2 → XP_024843873.1  rho guanine nucleotide exchange factor 6 isoform X6

      Conserved Domains (5) summary
      cd12060
      Location:8 → 65
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296 → 393
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:424 → 528
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:531 → 617
      betaPIX_CC; betaPIX coiled coil

    9. XM_059883473.1 → XP_059739456.1  rho guanine nucleotide exchange factor 6 isoform X7

    10. XM_059883475.1 → XP_059739458.1  rho guanine nucleotide exchange factor 6 isoform X7

    11. XM_059883472.1 → XP_059739455.1  rho guanine nucleotide exchange factor 6 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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