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    MARCHF6 membrane associated ring-CH-type finger 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 540371, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MARCHF6provided by VGNC
    Official Full Name
    membrane associated ring-CH-type finger 6provided by VGNC
    Primary source
    VGNC:VGNC:31241
    See related
    BGD:BT17205; EnsemblRapid:ENSBTAG00070018736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MARCH6
    Orthologs
    human mouse all
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    Genomic context

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    See MARCHF6 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (62819405..62899708, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443012 Neighboring gene uncharacterized LOC112443013 Neighboring gene rhophilin associated tail protein 1 like Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene microRNA mir-6530 Neighboring gene carboxymethylenebutenolidase homolog Neighboring gene chaperonin containing TCP1 subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF6
    Names
    membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205812.3 → NP_001192741.1  E3 ubiquitin-protein ligase MARCHF6

      See identical proteins and their annotated locations for NP_001192741.1

      Status: VALIDATED

      Source sequence(s)
      EV626671, EV632242, EV706277, NKLS02000020
      UniProtKB/TrEMBL
      F1MHF0
      Related
      ENSBTAP00070025365.1, ENSBTAT00070042478.1
      Conserved Domains (2) summary
      smart00744
      Location:8 → 56
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
      PHA03419
      Location:125 → 214
      PHA03419; E4 protein; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      62819405..62899708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878770.1 → XP_059734753.1  E3 ubiquitin-protein ligase MARCHF6 isoform X2

      UniProtKB/TrEMBL
      A0AAA9S2H9, F1MHF0
      Related
      ENSBTAP00070025380.1, ENSBTAT00070042503.1

    2. XM_024981358.2 → XP_024837126.1  E3 ubiquitin-protein ligase MARCHF6 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0G2
      Related
      ENSBTAP00070025351.1, ENSBTAT00070042454.1
      Conserved Domains (1) summary
      COG5183
      Location:314 → 840
      SSM4; E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]

    3. XM_024981357.2 → XP_024837125.1  E3 ubiquitin-protein ligase MARCHF6 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0G2
      Conserved Domains (1) summary
      COG5183
      Location:314 → 840
      SSM4; E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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