U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CASP1 caspase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 514214, updated on 30-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    CASP1provided by VGNC
    Official Full Name
    caspase 1provided by VGNC
    Primary source
    VGNC:VGNC:106669
    See related
    BGD:BT18347; EnsemblRapid:ENSBTAG00070014964
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CASP1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (3233013..3248233)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene proteasomal ATPase-associated factor 1-like Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene caspase 4, apoptosis-related cysteine peptidase Neighboring gene RNA-binding protein EWS-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from holstein cows. Ahmed M, et al. J Vet Med Sci, 2007 May. PMID 17551224
    2. The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1β through caspase 1 in bovine macrophages. Morales-Aguilar A, et al. Res Vet Sci, 2020 Aug. PMID 32335355
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1beta through caspase 1 in bovine macrophages.
      Title: The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1β through caspase 1 in bovine macrophages.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables caspase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AIM2 inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of IPAF inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of NLRP3 inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    caspase-1
    Names
    caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
    XP_002692967.2
    XP_005215796.2
    XP_024831468.1
    XP_059731040.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3233013..3248233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002692921.6 → XP_002692967.2  caspase-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MFA5, A0PCH9
      Related
      ENSBTAP00070020058.1, ENSBTAT00070033875.1
      Conserved Domains (2) summary
      smart00115
      Location:152 → 401
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:6 → 87
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    2. XM_005215739.5 → XP_005215796.2  caspase-1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LS96
      Related
      ENSBTAP00070020062.1, ENSBTAT00070033879.1
      Conserved Domains (2) summary
      smart00115
      Location:132 → 381
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:6 → 87
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    3. XM_059875057.1 → XP_059731040.1  caspase-1 isoform X4

    4. XM_024975700.2 → XP_024831468.1  caspase-1 isoform X3

      Conserved Domains (1) summary
      smart00115
      Location:64 → 313
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials