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    MME membrane metalloendopeptidase [ Bos taurus (domestic cattle) ]

    Gene ID: 536741, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MMEprovided by VGNC
    Official Full Name
    membrane metalloendopeptidaseprovided by VGNC
    Primary source
    VGNC:VGNC:31514
    See related
    BGD:BT19724; Ensembl:ENSBTAG00000002075
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MME in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (112478989..112596003, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene small transmembrane regulator of ion transport 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P pseudogene Neighboring gene transfer RNA lysine (anticodon UUU)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production. Fitzpatrick PA, et al. Int J Biochem Cell Biol, 2009 Nov. PMID 19464387
    2. The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling. Song S, et al. Cell Signal, 2016 Oct. PMID 27373199
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
      Title: The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling.
    2. NEP expression is down-regulated in vascular endothelial cells by physiological laminar shear, possibly via a mechanotransduction mechanism involving NADPH oxidase-induced reactive oxygen species production.[Neprilysin]
      Title: Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neprilysin
    NP_001179813.1
    XP_024846345.1
    XP_024846352.1
    XP_024846356.1
    XP_024846360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192884.1 → NP_001179813.1  neprilysin

      See identical proteins and their annotated locations for NP_001179813.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000001
      UniProtKB/TrEMBL
      A0AAA9SFC6, E1BPL8
      Related
      ENSBTAP00000002681.4, ENSBTAT00000002681.5
      Conserved Domains (1) summary
      cd08662
      Location:77 → 748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      112478989..112596003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990592.2 → XP_024846360.1  neprilysin isoform X2

      UniProtKB/TrEMBL
      A0AAA9RZG8, A0AAA9SFC6
      Related
      ENSBTAP00000076726.1, ENSBTAT00000098025.1
      Conserved Domains (1) summary
      cd08662
      Location:70 → 694
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    2. XM_024990577.2 → XP_024846345.1  neprilysin isoform X1

      UniProtKB/TrEMBL
      A0AAA9SFC6, E1BPL8
      Conserved Domains (1) summary
      cd08662
      Location:77 → 748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    3. XM_024990584.2 → XP_024846352.1  neprilysin isoform X1

      UniProtKB/TrEMBL
      A0AAA9SFC6, E1BPL8
      Conserved Domains (1) summary
      cd08662
      Location:77 → 748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    4. XM_024990588.2 → XP_024846356.1  neprilysin isoform X1

      UniProtKB/TrEMBL
      A0AAA9SFC6, E1BPL8
      Related
      ENSBTAP00000081154.1, ENSBTAT00000123879.1
      Conserved Domains (1) summary
      cd08662
      Location:77 → 748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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