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    HYAL2 hyaluronidase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281838, updated on 29-Jan-2025

    Summary

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    Official Symbol
    HYAL2provided by VGNC
    Official Full Name
    hyaluronidase 2provided by VGNC
    Primary source
    VGNC:VGNC:30011
    See related
    BGD:BT17740; Ensembl:ENSBTAG00000000484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HYAL2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (50018150..50026835)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene zinc finger MYND-type containing 10 Neighboring gene Ras association domain family member 1 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronidase 1 Neighboring gene N-alpha-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronidase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Critical role of hyaluronidase-2 during preimplantation embryo development. Marei WF, et al. Mol Hum Reprod, 2013 Sep. PMID 23625939
    2. Mechanism of cell entry and transformation by enzootic nasal tumor virus. Dirks C, et al. J Virol, 2002 Mar. PMID 11836391, Free PMC Article
    3. CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2. Hida D, et al. Matrix Biol, 2015 Oct. PMID 25864644, Free PMC Article
    4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126904

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hyaluronoglucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hyalurononglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hyaluronan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hyaluronidase-2
    Names
    hyal-2
    hyaluronoglucosaminidase 2
    NP_776772.1
    XP_010815967.1
    XP_010815968.1
    XP_024838158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174347.2 → NP_776772.1  hyaluronidase-2 precursor

      See identical proteins and their annotated locations for NP_776772.1

      Status: PROVISIONAL

      Source sequence(s)
      AF411973
      UniProtKB/Swiss-Prot
      Q8SQG8
      UniProtKB/TrEMBL
      Q58D43
      Related
      ENSBTAP00070049666.1, ENSBTAT00070081992.1
      Conserved Domains (1) summary
      pfam01630
      Location:29 → 361
      Glyco_hydro_56; Hyaluronidase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50018150..50026835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010817665.4 → XP_010815967.1  hyaluronidase-2 isoform X1

      See identical proteins and their annotated locations for XP_010815967.1

      UniProtKB/Swiss-Prot
      Q8SQG8
      UniProtKB/TrEMBL
      Q58D43
      Conserved Domains (1) summary
      pfam01630
      Location:29 → 361
      Glyco_hydro_56; Hyaluronidase

    2. XM_010817666.4 → XP_010815968.1  hyaluronidase-2 isoform X1

      See identical proteins and their annotated locations for XP_010815968.1

      UniProtKB/Swiss-Prot
      Q8SQG8
      UniProtKB/TrEMBL
      Q58D43
      Conserved Domains (1) summary
      pfam01630
      Location:29 → 361
      Glyco_hydro_56; Hyaluronidase

    3. XM_024982390.2 → XP_024838158.1  hyaluronidase-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8SQG8
      UniProtKB/TrEMBL
      Q58D43
      Conserved Domains (1) summary
      pfam01630
      Location:29 → 361
      Glyco_hydro_56; Hyaluronidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SQG8.1 GenPept UniProtKB/Swiss-Prot:Q8SQG8

    Gene LinkOut

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