U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LRPAP1 LDL receptor related protein associated protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 504957, updated on 29-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    LRPAP1provided by VGNC
    Official Full Name
    LDL receptor related protein associated protein 1provided by VGNC
    Primary source
    VGNC:VGNC:30995
    See related
    BGD:BT29575; Ensembl:ENSBTAG00000000073
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LRPAP1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (115369855..115383647)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene adrenoceptor alpha 2C Neighboring gene microRNA mir-1777a Neighboring gene docking protein 7 Neighboring gene HGF activator

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC139402

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables very-low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of very-low-density lipoprotein particle clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-2-macroglobulin receptor-associated protein
    Names
    low density lipoprotein receptor-related protein associated protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080225.1 → NP_001073694.1  alpha-2-macroglobulin receptor-associated protein precursor

      See identical proteins and their annotated locations for NP_001073694.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118191
      UniProtKB/TrEMBL
      A0A3Q1MD85, F6RBT3, Q148K7
      Related
      ENSBTAP00070034209.1, ENSBTAT00070057405.1
      Conserved Domains (5) summary
      cd14806
      Location:62 → 71
      RAP_D1; 3-helical coiled coil [structural motif]
      cd14807
      Location:151 → 248
      RAP_D2; Domain 2 of receptor-associated protein (RAP)
      cd14808
      Location:257 → 362
      RAP_D3; C-terminal receptor-associated protein (RAP), Domain 3
      pfam06400
      Location:29 → 135
      Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain
      pfam06401
      Location:151 → 362
      Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      115369855..115383647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993096.2 → XP_024848864.1  alpha-2-macroglobulin receptor-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MD85
      Conserved Domains (3) summary
      cd14806
      Location:62 → 71
      RAP_D1; 3-helical coiled coil [structural motif]
      pfam06400
      Location:29 → 135
      Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain
      pfam06401
      Location:151 → 363
      Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials