ADAM12 ADAM metallopeptidase domain 12 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ADAM12provided by VGNC
Official Full Name: ADAM metallopeptidase domain 12provided by VGNC
Primary source: VGNC:VGNC:25605
See related: BGD:BT24687; Ensembl:ENSBTAG00000012444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (45513530..45903613, complement)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein.
Title: Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein.
These findings suggest ADAM12 is upregulated in muscles with more slow-oxidative myofibres, such as the LM, and is linked to type I myofibers in cattle.
Title: A disintegrin and metalloprotease-12 is type I myofiber specific in Bos taurus and Bos indicus cattle.
The 5'- and 3'-regions of bovive ADAM12 have been analysed and compared to the human gene, and the promoter region has been cloned and sequenced.
Title: Genomic organization and promoter analysis of the bovine ADAM12 gene.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 12

Names: meltrin alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001156.1 → NP_001001156.1 disintegrin and metalloproteinase domain-containing protein 12 precursor

See identical proteins and their annotated locations for NP_001001156.1

Status: PROVISIONAL

Source sequence(s)

AB164682

UniProtKB/TrEMBL

F1MW52, Q75PQ9

Related

ENSBTAP00070034133.1, ENSBTAT00070057234.1

Conserved Domains (6) summary

smart00050
Location:447 → 515

DISIN; Homologues of snake disintegrins

smart00608
Location:518 → 660

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:222 → 422

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:222 → 424

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:71 → 171

Pep_M12B_propep; Reprolysin family propeptide

pfam17093
Location:796 → 888

PBP_N; Penicillin-binding protein N-terminus