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    STAC SH3 and cysteine rich domain [ Bos taurus (domestic cattle) ]

    Gene ID: 524215, updated on 30-Jan-2025

    Summary

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    Official Symbol
    STACprovided by VGNC
    Official Full Name
    SH3 and cysteine rich domainprovided by VGNC
    Primary source
    VGNC:VGNC:35350
    See related
    BGD:BT27225; EnsemblRapid:ENSBTAG00070020414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See STAC in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (9887461..10240906)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene cAMP regulated phosphoprotein 21 Neighboring gene microRNA mir-128-2 Neighboring gene uncharacterized LOC104975489 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC100848011 Neighboring gene LRR binding FLII interacting protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC152116

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH3 and cysteine-rich domain-containing protein
    Names
    SRC homology 3 and cysteine-rich domain protein
    SRC homology 3 and cysteine-rich domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077962.2 → NP_001071430.1  SH3 and cysteine-rich domain-containing protein

      See identical proteins and their annotated locations for NP_001071430.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126707
      UniProtKB/Swiss-Prot
      A0JNJ1
      UniProtKB/TrEMBL
      A0AAA9TYR9
      Related
      ENSBTAP00070027596.1, ENSBTAT00070046107.1
      Conserved Domains (4) summary
      cd11833
      Location:290 → 342
      SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
      cd00029
      Location:109 → 160
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:167 → 262
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:349 → 399
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9887461..10240906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059879684.1 → XP_059735667.1  SH3 and cysteine-rich domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A0AAA9S6U9, A0AAA9TYR9

    2. XM_059879685.1 → XP_059735668.1  SH3 and cysteine-rich domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A0AAA9S6U9, A0AAA9TYR9

    3. XM_059879687.1 → XP_059735670.1  SH3 and cysteine-rich domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A0AAA9S6U9, A0AAA9TYR9
      Related
      ENSBTAP00070027611.1, ENSBTAT00070046131.1

    4. XM_059879688.1 → XP_059735671.1  SH3 and cysteine-rich domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A0AAA9S6U9, A0AAA9TYR9

    5. XM_010817462.4 → XP_010815764.2  SH3 and cysteine-rich domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0AAA9TYR9
      Conserved Domains (4) summary
      cd11833
      Location:290 → 342
      SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
      cd00029
      Location:109 → 160
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:167 → 238
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:349 → 372
      SH3; Src Homology 3 domain superfamily

    6. XM_005222469.5 → XP_005222526.2  SH3 and cysteine-rich domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0AAA9TYR9
      Conserved Domains (4) summary
      cd11833
      Location:290 → 342
      SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
      cd00029
      Location:109 → 160
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:167 → 238
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:349 → 373
      SH3; Src Homology 3 domain superfamily

    7. XM_059879683.1 → XP_059735666.1  SH3 and cysteine-rich domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0AAA9TYR9, A0AAF6YQQ8
      Related
      ENSBTAP00070027602.1, ENSBTAT00070046120.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JNJ1.1 GenPept UniProtKB/Swiss-Prot:A0JNJ1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials