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    SHC1 SHC adaptor protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 507196, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SHC1provided by VGNC
    Official Full Name
    SHC adaptor protein 1provided by VGNC
    Primary source
    VGNC:VGNC:34590
    See related
    BGD:BT18799; EnsemblRapid:ENSBTAG00070007410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    p66shc
    Orthologs
    human mouse all
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    Genomic context

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    See SHC1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (15616404..15626916)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene lens epithelial protein Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene uncharacterized LOC132344832 Neighboring gene pygopus family PHD finger 2 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE). Streese L, et al. Eur Heart J, 2020 Apr 14. PMID 31323685
    2. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. Betts DH, et al. PLoS One, 2014. PMID 24475205, Free PMC Article
    3. Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos. Bain NT, et al. Mol Reprod Dev, 2013 Jan. PMID 23109234
    4. The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro. Favetta LA, et al. BMC Dev Biol, 2007 Nov 29. PMID 18047664, Free PMC Article
    5. High levels of p66shc and intracellular ROS in permanently arrested early embryos. Favetta LA, et al. Free Radic Biol Med, 2007 Apr 15. PMID 17382201

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE).
      Title: High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE).
    2. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.
      Title: The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.
    3. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase.
      Title: Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos.
    4. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.
      Title: Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation.
    5. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos
      Title: The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro.
    6. p66shc, but not p53, is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.
      Title: High levels of p66shc and intracellular ROS in permanently arrested early embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SHC-transforming protein 1
    Names
    SH2 domain protein C1
    SHC (Src homology 2 domain containing) transforming protein 1
    src homology 2 domain-containing-transforming protein C1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075305.2 → NP_001068773.1  SHC-transforming protein 1 isoform b

      See identical proteins and their annotated locations for NP_001068773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      BC122688, EH179100, EV724133
      UniProtKB/Swiss-Prot
      Q0IIE2, Q45KX9
      UniProtKB/TrEMBL
      A0AAF6ZE69
      Related
      ENSBTAP00070009786.1, ENSBTAT00070016874.1
      Conserved Domains (3) summary
      cd09925
      Location:370 → 473
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36 → 207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:264 → 400
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. NM_001164061.1 → NP_001157533.1  SHC-transforming protein 1 isoform a

      See identical proteins and their annotated locations for NP_001157533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC122688, EE957359, EV724133
      UniProtKB/TrEMBL
      A0AAF6ZE69
      Conserved Domains (2) summary
      cd09925
      Location:480 → 583
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15616404..15626916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059882857.1 → XP_059738840.1  SHC-transforming protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAF6ZE69

    2. XM_059882853.1 → XP_059738836.1  SHC-transforming protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAF6ZE69

    3. XM_059882861.1 → XP_059738844.1  SHC-transforming protein 1 isoform X2

      UniProtKB/TrEMBL
      A0AAF6ZE69
      Related
      ENSBTAP00070009808.1, ENSBTAT00070016910.1

    4. XM_059882865.1 → XP_059738848.1  SHC-transforming protein 1 isoform X3

      UniProtKB/TrEMBL
      A0AAF6ZE69, E1B716
      Related
      ENSBTAP00070009754.1, ENSBTAT00070016804.1

    5. XM_059882866.1 → XP_059738849.1  SHC-transforming protein 1 isoform X4

      UniProtKB/TrEMBL
      A0AAF6ZE69

    6. XM_005203675.5 → XP_005203732.1  SHC-transforming protein 1 isoform X6

      See identical proteins and their annotated locations for XP_005203732.1

      UniProtKB/TrEMBL
      A0AAF6ZE69
      Conserved Domains (2) summary
      cd09925
      Location:389 → 492
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36 → 225
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    7. XM_005203673.5 → XP_005203730.1  SHC-transforming protein 1 isoform X5

      See identical proteins and their annotated locations for XP_005203730.1

      UniProtKB/TrEMBL
      A0AAF6ZE69
      Conserved Domains (2) summary
      cd09925
      Location:392 → 495
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39 → 228
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    8. XM_024986715.2 → XP_024842483.1  SHC-transforming protein 1 isoform X7

      UniProtKB/TrEMBL
      A0AAF6ZE69
      Conserved Domains (3) summary
      cd09925
      Location:374 → 477
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39 → 210
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:267 → 397
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    9. XM_024986719.2 → XP_024842487.1  SHC-transforming protein 1 isoform X8

      UniProtKB/TrEMBL
      A0AAF6ZE69, A0AAF7A490
      Conserved Domains (3) summary
      cd09925
      Location:373 → 476
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39 → 210
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:267 → 396
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0IIE2.1 GenPept UniProtKB/Swiss-Prot:Q0IIE2

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