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    P4HA2 prolyl 4-hydroxylase subunit alpha 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 507327, updated on 27-Dec-2024

    Summary

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    Official Symbol
    P4HA2provided by VGNC
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 2provided by VGNC
    Primary source
    VGNC:VGNC:32536
    See related
    BGD:BT12482; Ensembl:ENSBTAG00000001116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See P4HA2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (22147086..22218087)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 5 Neighboring gene solute carrier family 22 member 4 Neighboring gene microRNA mir-2457 Neighboring gene PDZ and LIM domain 4 Neighboring gene uncharacterized LOC132345720 Neighboring gene microRNA mir-12040 Neighboring gene transfer RNA tyrosine (anticodon AUA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127031

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-2
    Names
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
    NP_001029465.2
    NP_001152881.1
    XP_005209093.1
    XP_005209095.1
    XP_015327591.1
    XP_024849751.1
    XP_024849752.1
    XP_059743994.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034293.2 → NP_001029465.2  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001029465.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1. The resulting isoform (2) contains an alternate internal segment, compared to isoform 1.
      Source sequence(s)
      CB422491, CK833494, EE358954, EE383429, EE982650
      UniProtKB/TrEMBL
      F1MJQ4
      Related
      ENSBTAP00000001479.5, ENSBTAT00000001479.6
      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. NM_001159409.1 → NP_001152881.1  prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001152881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CK833494, CV982421, EE358954, EE383429, EE982650
      UniProtKB/TrEMBL
      F1MJQ4, G3N2F2
      Related
      ENSBTAP00000056064.1, ENSBTAT00000064203.2
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22147086..22218087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993983.2 → XP_024849751.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      F1MJQ4
      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_059888011.1 → XP_059743994.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      F1MJQ4, G3N2F2

    3. XM_005209036.5 → XP_005209093.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_005209093.1

      UniProtKB/TrEMBL
      F1MJQ4, G3N2F2
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_024993984.2 → XP_024849752.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      F1MJQ4
      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_005209038.5 → XP_005209095.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_005209095.1

      UniProtKB/TrEMBL
      F1MJQ4, G3N2F2
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_015472105.3 → XP_015327591.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      F1MJQ4
      Conserved Domains (2) summary
      smart00702
      Location:346 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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