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    VRK3 VRK serine/threonine kinase 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 520302, updated on 29-Jan-2025

    Summary

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    Official Symbol
    VRK3provided by VGNC
    Official Full Name
    VRK serine/threonine kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:36836
    See related
    BGD:BT25587; Ensembl:ENSBTAG00000005367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See VRK3 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (56291590..56327575, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene interleukin 4 induced 1 Neighboring gene nucleoporin 62 Neighboring gene activating transcription factor 5 Neighboring gene sialic acid binding Ig like lectin 11 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC132342717 Neighboring gene zinc finger protein 473 Neighboring gene IZUMO family member 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC133825

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase VRK3
    Names
    inactive serine/threonine-protein kinase VRK3
    serine/threonine-protein pseudokinase VRK3
    vaccinia related kinase 3
    NP_001039716.1
    XP_005219336.1
    XP_005219337.1
    XP_005219338.1
    XP_024834027.1
    XP_024834028.1
    XP_024834029.1
    XP_024834030.1
    XP_024834031.1
    XP_059732718.1
    XP_059732719.1
    XP_059732720.1
    XP_059732721.1
    XP_059732722.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046251.2 → NP_001039716.1  serine/threonine-protein kinase VRK3

      See identical proteins and their annotated locations for NP_001039716.1

      Status: PROVISIONAL

      Source sequence(s)
      BC110135
      UniProtKB/Swiss-Prot
      Q2YDN8
      UniProtKB/TrEMBL
      A0AAA9SUY9
      Related
      ENSBTAP00070050457.1, ENSBTAT00070083566.1
      Conserved Domains (5) summary
      COG0515
      Location:188 → 447
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam04880
      Location:25 → 110
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      pfam13240
      Location:3 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:132 → 434
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56291590..56327575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876738.1 → XP_059732721.1  serine/threonine-protein kinase VRK3 isoform X4

      UniProtKB/TrEMBL
      A0AAA9S8B6, A0AAA9SUK7

    2. XM_005219281.5 → XP_005219338.1  serine/threonine-protein kinase VRK3 isoform X3

      See identical proteins and their annotated locations for XP_005219338.1

      UniProtKB/Swiss-Prot
      Q2YDN8
      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (5) summary
      COG0515
      Location:188 → 447
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam04880
      Location:25 → 110
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      pfam13240
      Location:3 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:132 → 434
      PKc_like; Protein Kinases, catalytic domain

    3. XM_024978263.2 → XP_024834031.1  serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (2) summary
      pfam13240
      Location:2 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:140 → 442
      PKc_like; Protein Kinases, catalytic domain

    4. XM_059876735.1 → XP_059732718.1  serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SUY9

    5. XM_059876737.1 → XP_059732720.1  serine/threonine-protein kinase VRK3 isoform X4

      UniProtKB/TrEMBL
      A0AAA9S8B6, A0AAA9SUK7
      Related
      ENSBTAP00070050452.1, ENSBTAT00070083546.1

    6. XM_005219279.5 → XP_005219336.1  serine/threonine-protein kinase VRK3 isoform X3

      See identical proteins and their annotated locations for XP_005219336.1

      UniProtKB/Swiss-Prot
      Q2YDN8
      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (5) summary
      COG0515
      Location:188 → 447
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam04880
      Location:25 → 110
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      pfam13240
      Location:3 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:132 → 434
      PKc_like; Protein Kinases, catalytic domain

    7. XM_024978260.2 → XP_024834028.1  serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (2) summary
      pfam13240
      Location:2 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:140 → 442
      PKc_like; Protein Kinases, catalytic domain

    8. XM_024978262.2 → XP_024834030.1  serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (2) summary
      pfam13240
      Location:2 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:140 → 442
      PKc_like; Protein Kinases, catalytic domain

    9. XM_005219280.5 → XP_005219337.1  serine/threonine-protein kinase VRK3 isoform X3

      See identical proteins and their annotated locations for XP_005219337.1

      UniProtKB/Swiss-Prot
      Q2YDN8
      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (5) summary
      COG0515
      Location:188 → 447
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam04880
      Location:25 → 110
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      pfam13240
      Location:3 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:132 → 434
      PKc_like; Protein Kinases, catalytic domain

    10. XM_024978259.2 → XP_024834027.1  serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (2) summary
      pfam13240
      Location:2 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:140 → 442
      PKc_like; Protein Kinases, catalytic domain

    11. XM_024978261.2 → XP_024834029.1  serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SUY9
      Conserved Domains (2) summary
      pfam13240
      Location:2 → 24
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:140 → 442
      PKc_like; Protein Kinases, catalytic domain

    12. XM_059876736.1 → XP_059732719.1  serine/threonine-protein kinase VRK3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SUY9
      Related
      ENSBTAP00070050455.1, ENSBTAT00070083559.1

    13. XM_059876739.1 → XP_059732722.1  serine/threonine-protein kinase VRK3 isoform X5

      UniProtKB/TrEMBL
      A0AAA9SUK7
      Related
      ENSBTAP00070050454.1, ENSBTAT00070083553.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YDN8.1 GenPept UniProtKB/Swiss-Prot:Q2YDN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials