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    DPYSL2 dihydropyrimidinase like 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 533746, updated on 1-Jan-2025

    Summary

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    Official Symbol
    DPYSL2provided by VGNC
    Official Full Name
    dihydropyrimidinase like 2provided by VGNC
    Primary source
    VGNC:VGNC:28195
    See related
    BGD:BT28579; Ensembl:ENSBTAG00000018373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DRP-2; CRMP-2; TOAD-64
    Orthologs
    human mouse all
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    Genomic context

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    See DPYSL2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (73756755..73875381)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein 3 like Neighboring gene 5S ribosomal RNA Neighboring gene PNMA family member 2 Neighboring gene adrenoceptor alpha 1A Neighboring gene stathmin 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. Rahajeng J, et al. J Biol Chem, 2010 Oct 15. PMID 20801876, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydropyrimidinase-related protein 2
    Names
    collapsin response mediator protein 2
    neural-specific protein NSP60
    turned on after division 64

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076000.2 → NP_001069468.1  dihydropyrimidinase-related protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001069468.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000008
      UniProtKB/Swiss-Prot
      O02675, Q29RI7
      UniProtKB/TrEMBL
      A0A3Q1MQ68
      Related
      ENSBTAP00000024448.4, ENSBTAT00000024448.6
      Conserved Domains (1) summary
      cd01314
      Location:17 → 466
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

    2. NM_001434924.1 → NP_001421853.1  dihydropyrimidinase-related protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000008

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      73756755..73875381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005210288.5 → XP_005210345.1  dihydropyrimidinase-related protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005210345.1

      UniProtKB/TrEMBL
      A0AAA9SKM9
      Conserved Domains (1) summary
      cd01314
      Location:1 → 430
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02675.1 GenPept UniProtKB/Swiss-Prot:O02675

    Gene LinkOut

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