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    HSF1 heat shock transcription factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 506235, updated on 29-Jan-2025

    Summary

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    Official Symbol
    HSF1provided by VGNC
    Official Full Name
    heat shock transcription factor 1provided by VGNC
    Primary source
    VGNC:VGNC:29981
    See related
    BGD:BT12620; Ensembl:ENSBTAG00000020751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HSF
    Orthologs
    human mouse all
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    Genomic context

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    See HSF1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (614022..633762, complement)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 249 Neighboring gene scratch family transcriptional repressor 1 Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene BOP1 ribosomal biogenesis factor Neighboring gene scleraxis bHLH transcription factor Neighboring gene maestro heat like repeat family member 1 Neighboring gene microRNA mir-1839

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of long terminal repeat of bovine leukemia virus by bovine heat shock factor 1. Hachiya Y, et al. Virus Res, 2019 Aug. PMID 31228509
    2. Cellular thermotolerance is independent of HSF 1 expression in zebu and crossbred non-lactating cattle. Gill JK, et al. Int J Biometeorol, 2017 Sep. PMID 28451769
    3. Two novel SNPs in HSF1 gene are associated with thermal tolerance traits in Chinese Holstein cattle. Li QL, et al. DNA Cell Biol, 2011 Apr. PMID 21189066
    4. Differential expression of HSF1 and HSPA6 genes and physiological responses in Angus and Simmental cattle breeds. de Fátima Bretanha Rocha R, et al. J Therm Biol, 2019 Aug. PMID 31466795
    5. Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Winter A, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12077321, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We conclude that Bovine leukemia virus long terminal repeat is activated to a basal level by host transcriptional factor HSF1, but without Tax protein involvement.
      Title: Transcriptional activation of long terminal repeat of bovine leukemia virus by bovine heat shock factor 1.
    2. Respiratory rate, rectal temperature and expression of the HSF1 and HSPA6 genes can be indicators of thermotolerance in taurine cattle.
      Title: Differential expression of HSF1 and HSPA6 genes and physiological responses in Angus and Simmental cattle breeds.
    3. The association between the HSF 1 expression and antioxidative activity through correlation analysis was found to be non-significant, though enzymatic activity appeared to behave in a similar fashion in both breeds at 5% level of significance, thus ruling out the role of HSF1 expression level on the activity of enzymes involved in oxidative stress in vitro in zebu and crossbred cattle.
      Title: Cellular thermotolerance is independent of HSF 1 expression in zebu and crossbred non-lactating cattle.
    4. As the 4693-T mutation caused the disruption of microRNA target binding (resulting in the relief of the transcriptional repression), the HSF1 gene is useful in dairy cattle thermal tolerant breeding.
      Title: Two novel SNPs in HSF1 gene are associated with thermal tolerance traits in Chinese Holstein cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143130

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock factor protein 1
    Names
    HSF 1
    HSTF 1
    heat shock factor 1
    heat shock factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076809.1 → NP_001070277.1  heat shock factor protein 1

      See identical proteins and their annotated locations for NP_001070277.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123711
      UniProtKB/Swiss-Prot
      Q08DJ8
      UniProtKB/TrEMBL
      B6VAP5
      Conserved Domains (3) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:247 → 525
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:79 → 182
      PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      614022..633762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025001456.2 → XP_024857224.1  heat shock factor protein 1 isoform X7

      UniProtKB/TrEMBL
      B6VAP5
      Conserved Domains (3) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:247 → 526
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:79 → 182
      Transferase; Transferase family

    2. XM_005215151.5 → XP_005215208.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      B6VAP5
      Related
      ENSBTAP00070014360.1, ENSBTAT00070024120.1
      Conserved Domains (3) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:247 → 553
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:79 → 182
      PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

    3. XM_005215150.3 → XP_005215207.1  heat shock factor protein 1 isoform X3

      UniProtKB/TrEMBL
      B6VAP5
      Conserved Domains (3) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:247 → 554
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:79 → 182
      PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

    4. XM_010811828.3 → XP_010810130.1  heat shock factor protein 1 isoform X6

      UniProtKB/TrEMBL
      A0AAF6Z8G4, B6VAP5
      Related
      ENSBTAP00070014305.1, ENSBTAT00070024052.1
      Conserved Domains (2) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:258 → 536
      Vert_HS_TF; Vertebrate heat shock transcription factor

    5. XM_010811827.4 → XP_010810129.1  heat shock factor protein 1 isoform X5

      UniProtKB/TrEMBL
      B6VAP5
      Conserved Domains (2) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:258 → 537
      Vert_HS_TF; Vertebrate heat shock transcription factor

    6. XM_010811826.4 → XP_010810128.1  heat shock factor protein 1 isoform X2

      UniProtKB/TrEMBL
      B6VAP5
      Conserved Domains (2) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:258 → 564
      Vert_HS_TF; Vertebrate heat shock transcription factor

    7. XM_010811825.4 → XP_010810127.1  heat shock factor protein 1 isoform X1

      UniProtKB/TrEMBL
      B6VAP5
      Conserved Domains (2) summary
      smart00415
      Location:14 → 118
      HSF; heat shock factor
      pfam06546
      Location:258 → 565
      Vert_HS_TF; Vertebrate heat shock transcription factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08DJ8.1 GenPept UniProtKB/Swiss-Prot:Q08DJ8

    Gene LinkOut

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