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    AMT aminomethyltransferase [ Bos taurus (domestic cattle) ]

    Gene ID: 280719, updated on 29-Jan-2025

    Summary

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    Gene symbol
    AMT
    Gene description
    aminomethyltransferase
    See related
    BGD:BT25031; Ensembl:ENSBTAG00000002321
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See AMT in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (50693282..50697608)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene NEDD8-conjugating enzyme UBE2F-like Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene T cell leukemia translocation altered Neighboring gene ras homolog family member A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. cDNA sequence, in vitro synthesis, and intramitochondrial lipoylation of H-protein of the glycine cleavage system. Fujiwara K, et al. J Biol Chem, 1990 Oct 15. PMID 2211640
    2. Isolation and sequence determination of cDNA encoding T-protein of the glycine cleavage system. Okamura-Ikeda K, et al. J Biol Chem, 1991 Mar 15. PMID 2002038
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aminomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminomethyltransferase, mitochondrial
    Names
    GCVT
    aminomethyltransferase (glycine cleavage system protein T)
    glycine cleavage system T protein
    NP_803451.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177485.2 → NP_803451.1  aminomethyltransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_803451.1

      Status: PROVISIONAL

      Source sequence(s)
      M59799
      UniProtKB/Swiss-Prot
      P25285
      UniProtKB/TrEMBL
      A0AAA9TRT8
      Related
      ENSBTAP00070049243.1, ENSBTAT00070081136.1
      Conserved Domains (3) summary
      PLN02319
      Location:3 → 394
      PLN02319; aminomethyltransferase
      pfam01571
      Location:33 → 285
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:295 → 386
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50693282..50697608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25285.1 GenPept UniProtKB/Swiss-Prot:P25285

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