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    LAMB2 laminin, beta 2 (laminin S) [ Bos taurus (domestic cattle) ]

    Gene ID: 520167, updated on 29-Jan-2025

    Summary

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    Gene symbol
    LAMB2
    Gene description
    laminin, beta 2 (laminin S)
    See related
    Ensembl:ENSBTAG00000022635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See LAMB2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (50883620..50897890)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene laminin subunit beta-2 Neighboring gene laminin subunit beta-2 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene glutaminyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128643

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in basement membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of laminin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laminin subunit beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046247.2 → NP_001039712.2  laminin subunit beta-2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC105436, CK963940, DT810209, DT811149, DV875815, DV920193, EE366453, EE385105, EH174117, EV706949
      UniProtKB/TrEMBL
      E1BDK6
      Related
      ENSBTAP00070049488.1, ENSBTAT00070081723.1
      Conserved Domains (7) summary
      smart00180
      Location:787 → 832
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:525 → 566
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:1147 → 1186
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:61 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam12795
      Location:1482 → 1777
      MscS_porin; Mechanosensitive ion channel porin domain
      cl02193
      Location:1555 → 1744
      VirB5_like; VirB5 protein family
      cl21478
      Location:1457 → 1545
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50883620..50897890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010817733.4 → XP_010816035.2  laminin subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      E1BDK6
      Conserved Domains (5) summary
      smart00180
      Location:787 → 832
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:525 → 566
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:1072 → 1111
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:65 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      cl25732
      Location:1127 → 1717
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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