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    HPRT1 hypoxanthine phosphoribosyltransferase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281229, updated on 29-Jan-2025

    Summary

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    Gene symbol
    HPRT1
    Gene description
    hypoxanthine phosphoribosyltransferase 1
    See related
    BGD:BT23983; Ensembl:ENSBTAG00000014685
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HPRT; HGPRT
    Orthologs
    human mouse all
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    Genomic context

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    See HPRT1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (18177361..18208571)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107131993 Neighboring gene coiled-coil domain containing 160 Neighboring gene U6 spliceosomal RNA Neighboring gene PHD finger protein 6 Neighboring gene microRNA mir-450a-1 Neighboring gene microRNA mir-450b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Clarifications on breakpoints in HSAX and BTAX by comparative mapping of F9, HPRT, and XIST in cattle. Goldammer T, et al. Cytogenet Genome Res, 2003. PMID 14571135
    2. Forms of selenium in vitamin-mineral mixes differentially affect serum alkaline phosphatase activity, and serum albumin and blood urea nitrogen concentrations, of steers grazing endophyte-infected tall fescue. Jia Y, et al. J Anim Sci, 2019 May 30. PMID 30957833, Free PMC Article
    3. Sex-chromosome linked gene expression in in-vitro produced bovine embryos. Peippo J, et al. Mol Hum Reprod, 2002 Oct. PMID 12356942
    4. Selection of reference genes for quantitative real-time PCR in bovine preimplantation embryos. Goossens K, et al. BMC Dev Biol, 2005 Dec 3. PMID 16324220, Free PMC Article
    5. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. levels of G6PD and HPRT RNA were higher in female morulae and blastocysts than in males
      Title: Sex-chromosome linked gene expression in in-vitro produced bovine embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128800

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hypoxanthine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in guanine salvage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hypoxanthine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hypoxanthine-guanine phosphoribosyltransferase
    Names
    HGPRTase
    hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)
    NP_001029207.1
    XP_059739256.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034035.2 → NP_001029207.1  hypoxanthine-guanine phosphoribosyltransferase

      Status: PROVISIONAL

      Source sequence(s)
      BC103248
      UniProtKB/Swiss-Prot
      Q3SZ18
      UniProtKB/TrEMBL
      Q1JP91
      Related
      ENSBTAP00070046118.1, ENSBTAT00070075562.1
      Conserved Domains (1) summary
      cl00309
      Location:3 → 218
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      18177361..18208571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059883273.1 → XP_059739256.1  hypoxanthine-guanine phosphoribosyltransferase isoform X1

      UniProtKB/TrEMBL
      A0AAA9S2N2, Q1JP91
      Related
      ENSBTAP00070046086.1, ENSBTAT00070075502.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SZ18.3 GenPept UniProtKB/Swiss-Prot:Q3SZ18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.