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    Tec tec protein tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tecprovided by RGD
    Official Full Name
    tec protein tyrosine kinaseprovided by RGD
    Primary source
    RGD:620973
    See related
    EnsemblRapid:ENSRNOG00000002278 AllianceGenome:RGD:620973
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in tissue regeneration. Predicted to be located in cell-cell junction and cytoskeleton. Predicted to be active in plasma membrane. Orthologous to human TEC (tec protein tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 121.4), Liver (RPKM 93.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tec in Genome Data Viewer
    Location:
    14p11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35706557..35815563)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35352551..35461585)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (37918884..38027953)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SLAIN motif family, member 2 Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene TXK tyrosine kinase Neighboring gene NIPA-like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF. Li F, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21094130
    2. Identification and characterization of differentially expressed genes in the early response phase during liver regeneration. Xu W, et al. Biochem Biophys Res Commun, 2000 Nov 19. PMID 11097837
    3. Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Hamazaki Y, et al. Oncogene, 1998 May 28. PMID 9652744
    4. Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. Laffargue M, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299487
    5. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Ohya K, et al. Proc Natl Acad Sci U S A, 1999 Oct 12. PMID 10518561, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase Tec
    Names
    cytoplasmic tyrosine kinase, Dscr28C related
    NP_445884.1
    XP_038948440.1
    XP_038948441.1
    XP_038948442.1
    XP_063129753.1
    XP_063129754.1
    XP_063129755.1
    XP_063129756.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053432.1 → NP_445884.1  tyrosine-protein kinase Tec

      See identical proteins and their annotated locations for NP_445884.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166730
      UniProtKB/TrEMBL
      A0A8I5ZXG2, B2RYC7
      Related
      ENSRNOP00000003125.5, ENSRNOT00000003125.7
      Conserved Domains (4) summary
      cd10396
      Location:238 → 345
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11905
      Location:181 → 235
      SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
      cd01238
      Location:7 → 148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      cd05114
      Location:363 → 622
      PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      35706557..35815563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273685.1 → XP_063129755.1  tyrosine-protein kinase Tec isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXG2, A0A8I6A3K6

    2. XM_039092512.2 → XP_038948440.1  tyrosine-protein kinase Tec isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXG2, B2RYC7
      Related
      ENSRNOP00000075313.1, ENSRNOT00000088441.3
      Conserved Domains (4) summary
      cd10396
      Location:238 → 345
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11905
      Location:181 → 235
      SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
      cd01238
      Location:7 → 148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      cd05114
      Location:363 → 622
      PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

    3. XM_063273683.1 → XP_063129753.1  tyrosine-protein kinase Tec isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXG2, A0A8I6A3K6

    4. XM_039092513.2 → XP_038948441.1  tyrosine-protein kinase Tec isoform X4

      Conserved Domains (4) summary
      cd10396
      Location:238 → 345
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11905
      Location:181 → 235
      SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
      cd01238
      Location:7 → 148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      cl21453
      Location:363 → 488
      PKc_like; Protein Kinases, catalytic domain

    5. XM_063273684.1 → XP_063129754.1  tyrosine-protein kinase Tec isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXG2, A0A8I6A3K6

    6. XM_063273686.1 → XP_063129756.1  tyrosine-protein kinase Tec isoform X3

      UniProtKB/TrEMBL
      Q9EQ78

    7. XM_039092514.2 → XP_038948442.1  tyrosine-protein kinase Tec isoform X5

      UniProtKB/TrEMBL
      Q9EQ78
      Conserved Domains (4) summary
      cd10396
      Location:156 → 263
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11905
      Location:99 → 153
      SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
      cd05114
      Location:281 → 540
      PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
      cl17171
      Location:10 → 66
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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