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    Pcp4 Purkinje cell protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25510, updated on 27-Nov-2024

    Summary

    Symbol
    Pcp4provided by RGD
    Full Name
    Purkinje cell protein 4provided by RGD
    Primary source
    RGD:3271
    See related
    EnsemblRapid:ENSRNOG00000001628 AllianceGenome:RGD:3271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PEPZ19; pep-19
    Summary
    The protein encoded by this gene regulates H1˚ and H3.3 histone synthesis by binding to H1˚ and H3.3 histone mRNAs. The encoded protein can bind calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Brain (RPKM 1784.7) and Uterus (RPKM 207.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pcp4 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (49229185..49331186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35759711..35861725)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36851035..36912272)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene integrin beta-2-like, pseudogene 1 Neighboring gene immunoglobulin superfamily, member 5 Neighboring gene DS cell adhesion molecule Neighboring gene uncharacterized LOC102551331 Neighboring gene translin-associated factor X, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neurofilament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calmodulin regulator protein PCP4
    Names
    Neuron specific protein PEP-19 (Purkinje cell protein 4)
    brain-specific antigen PCP-4
    brain-specific polypeptide PEP-19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270538.2NP_001257467.1  calmodulin regulator protein PCP4 isoform LPI

      See identical proteins and their annotated locations for NP_001257467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, which causes a frameshift and use of a different start codon compared to variant 1. The resulting isoform (LPI) has a longer and distinct N-terminus compared to isoform PEP19. Experimental support for this transcript and isoform is provided in PMID:22020791 and PMID:17273800.
      Source sequence(s)
      CB613293, JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6A0K8, F7F9D7, Q8CHN7
      Related
      ENSRNOP00000002221.5, ENSRNOT00000002221.8
    2. NM_013002.4NP_037134.1  calmodulin regulator protein PCP4 isoform PEP19

      See identical proteins and their annotated locations for NP_037134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the smaller isoform (PEP19).
      Source sequence(s)
      CB613293, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P63055
      UniProtKB/TrEMBL
      A0A8I5ZX37
      Related
      ENSRNOP00000057764.2, ENSRNOT00000061047.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      49229185..49331186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088042.1XP_038943970.1  calmodulin regulator protein PCP4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX37