Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2j3provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily j, polypeptide 3provided by RGD
Primary source: RGD:631442
See related: EnsemblRapid:ENSRNOG00000077186 AllianceGenome:RGD:631442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2j9
Summary: Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 364.0), Brain (RPKM 44.4) and 4 other tissues See more
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Genomic context

Location:: 5q33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (116335755..116360677, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (111219921..111244987, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (115196982..115222084, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Title: Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Inflammation in astrocytes could down-regulate CYP2J3 mRNA, protein and activity. Inhibition of NF-kappaB prevented the down-regulation of CYP2J3 mRNA and protein .NF-kappaB is able to bind to at least two response elements in the promoter of Cyp2j3.
Title: Role of NF-κB in cytochrome P450 epoxygenases down-regulation during an inflammatory process in astrocytes.
Increases in CYP2J3 mRNA levels were observed in the frontal cortex, hippocampus, cerebellum, and brain stem from rats that received the subcutaneous injection with a subneurotoxic dose of monosodium l-glutamate.
Title: Glutamate affects the production of epoxyeicosanoids within the brain: The up-regulation of brain CYP2J through the MAPK-CREB signaling pathway.
Beneficial roles of the CYP epoxygenase 2J3 and its metabolites epoxyeicosatrienoic acids on adiponectin expression and secretion.
Title: CYP2J3 gene delivery up-regulated adiponectin expression via reduced endoplasmic reticulum stress in adipocytes.
Upregulation of CYP2J3/11,12-epoxyeicosatrienoic acid is involved in cardioprotection by inhibiting apoptosis via a caspase-dependent pathway.
Title: Upregulation of cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid inhibits apoptosis in neonatal rat cardiomyocytes by a caspase-dependent pathway.
The protein levels of CYP 2c6, 2e1 and 2j3 increased in the ischemic region of the rat hearts, while the mRNA levels of CYPs were unchanged.
Title: Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia.
CYP2J3-derived epoxyeicosatrienoic acids may alleviate insulin resistance at least in part through upregulated eNOS expression.
Title: CYP2J3 gene delivery reduces insulin resistance via upregulation of eNOS in fructose-treated rats.
endogenous activation of CYP2J3/EET may be an essential trigger leading to the protective effects of ischemic Post-conditioning, but not ischemic preconditioning, in the rat heart.
Title: Cytochrome P450 2J3/epoxyeicosatrienoic acids mediate the cardioprotection induced by ischaemic post-conditioning, but not preconditioning, in the rat.
Overexpression of CYP2J3 protects against diabetes and insulin resistance in peripheral tissues through activation of insulin receptor and AMP kinase pathways
Title: Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.
CYP2J3 is the principal P450 responsible for vitamin D3 25-hydroxylation in rat liver
Title: Identification of a novel rat microsomal vitamin D3 25-hydroxylase.

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General gene information

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Markers

AI145952 (e-PCR)
- UniSTS:245542

RH132385 (e-PCR)
- UniSTS:215668

Cyp2j9 (e-PCR), detects polymorphism
- UniSTS:546724

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate 11,12-epoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 14,15-epoxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables linoleic acid epoxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IEA Inferred from Electronic Annotation more info
involved_in linoleic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2J3

Names: CYPIIJ3; cytochrome P450 monooxygenase; cytochrome P450, 2j9; cytochrome P450, family 2, subfamily j, polypeptide 9

NP_786942.1

EC 1.14.14.1

XP_038965829.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175766.4 → NP_786942.1 cytochrome P450 2J3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51590, Q5EBD7

UniProtKB/TrEMBL

A6JRJ0, F1M032

Related

ENSRNOP00000054968.4, ENSRNOT00000058163.6

Conserved Domains (1) summary

pfam00067
Location:44 → 497

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

116335755..116360677 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109901.2 → XP_038965829.1 cytochrome P450 2J3 isoform X1

Conserved Domains (1) summary

cl41757
Location:1 → 354

cytochrome_P450; cytochrome P450 (CYP) superfamily