Spag6 sperm associated antigen 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spag6provided by MGI
Official Full Name: sperm associated antigen 6provided by MGI
Primary source: MGI:MGI:3040687
See related: Ensembl:ENSMUSG00000037708 AllianceGenome:MGI:3040687
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spag6l
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 33.0) See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 12.9 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (18698808..18754561)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (18694011..18749746)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have Different Biologic Functions In Vivo.
Title: The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have Different Biologic Functions In Vivo.
Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice.
Title: Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice.
SPAG6-silencing enhances decitabine-induced apoptosis and demethylation of PTEN in SKM-1 cells and in a xenograft mouse model.
Title: SPAG6-silencing enhances decitabine-induced apoptosis and demethylation of PTEN in SKM-1 cells and in a xenograft mouse model.
Planar cell polarity defects and hearing loss in sperm-associated antigen 6 (Spag6)-deficient mice.
Title: Planar cell polarity defects and hearing loss in sperm-associated antigen 6 (Spag6)-deficient mice.
multi-functional protein that not only regulates sperm motility, but also plays roles in spermatogenesis in multiple cellular compartments involving multiple protein partners
Title: The sperm-associated antigen 6 interactome and its role in spermatogenesis.
In this work, we performed a quantitative analysis of the expression of Spag6 and Spag16 genes in parallel with the immune-localization of the proteins in several tissues of adult mice.
Title: Distribution of sperm antigen 6 (SPAG6) and 16 (SPAG16) in mouse ciliated and non-ciliated tissues.
our data indicate that Spag6 plays an essential role in the process of neuronal proliferation and differentiation.
Title: The function of sperm-associated antigen 6 in neuronal proliferation and differentiation.
Data show reduced motility of sperm associated antigen 6 (Spag6)-deficient mouse embryonic fibroblasts (MEFs).
Title: Sperm Associated Antigen 6 (SPAG6) Regulates Fibroblast Cell Growth, Morphology, Migration and Ciliogenesis.
Spag6 was continuously expressed in the developing cerebral cortex. Overexpression of Spag6 caused a significant decrease in neurite number and length of cortical neurons.
Title: Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epithelial cilium movement involved in extracellular fluid movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sperm-associated antigen 6

Names: sperm associated antigen 6 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001334.3 → NP_001001334.2 sperm-associated antigen 6 isoform 1

See identical proteins and their annotated locations for NP_001001334.2

Status: VALIDATED

Source sequence(s)

AL928680

Consensus CDS

CCDS38051.1

UniProtKB/TrEMBL

Q3V0U9

Related

ENSMUSP00000092751.4, ENSMUST00000095132.10

Conserved Domains (3) summary

COG5064
Location:161 → 423

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00044
Location:335 → 369

HEAT; HEAT repeat [structural motif]

sd00043
Location:162 → 194

ARM; armadillo repeat [structural motif]
NM_001409584.1 → NP_001396513.1 sperm-associated antigen 6 isoform 1

Status: VALIDATED

Source sequence(s)

AL928680

UniProtKB/TrEMBL

Q3V0U9
NM_001409585.1 → NP_001396514.1 sperm-associated antigen 6 isoform 2

Status: VALIDATED

Source sequence(s)

AL928680