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    IFNG-AS1 IFNG regulatory antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100885789, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IFNG-AS1provided by HGNC
    Official Full Name
    IFNG regulatory antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:43910
    See related
    Ensembl:ENSG00000255733 AllianceGenome:HGNC:43910
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEST; Tmevpg1; GS1-410F4.2
    Expression
    Biased expression in lymph node (RPKM 3.8), appendix (RPKM 1.7) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IFNG-AS1 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (67989447..68021313)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (67968959..68000822)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68383227..68415093)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2421 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:68160813-68161536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:68166311-68166833 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:68221514-68222713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:68233883-68234382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:68270550-68271050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:68271051-68271551 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:68293706-68294442 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:68294443-68295177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:68313920-68314420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:68314421-68314921 Neighboring gene long intergenic non-protein coding RNA 1479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:68374855-68376054 Neighboring gene ribosomal protein L39 pseudogene 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6631 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 70 Neighboring gene 39S ribosomal protein L21, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study. Zedan MM, et al. Pediatr Rheumatol Online J, 2024 Apr 27. PMID 38678299, Free PMC Article
    2. Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice. Fu Y, et al. J Nanobiotechnology, 2024 Feb 17. PMID 38368393, Free PMC Article
    3. Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma. Wang Z, et al. Bioengineered, 2021 Dec. PMID 34872454, Free PMC Article
    4. Aberrant expression of long noncoding RNA TMEVPG1 in patients with primary immune thrombocytopenia. Li H, et al. Autoimmunity, 2016 Nov. PMID 27050808
    5. A potential marker in brucellosis, long non coding RNA IFNG-AS1. Gheitasi R, et al. Mol Biol Rep, 2019 Dec. PMID 31595441

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of long non-coding RNA IFNG-AS1 in autoimmune diseases.
      Title: The function of long non-coding RNA IFNG-AS1 in autoimmune diseases.
    2. Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study.
      Title: Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study.
    3. Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice.
      Title: Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice.
    4. Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma.
      Title: Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma.
    5. Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever.
      Title: Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever.
    6. Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis.
      Title: Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis.
    7. LncRNAs encoded by AC007278.2 and IFNG-AS1-001 showed significantly higher expression in relapsing Phase multiple sclerosis patients whereas IFNG-AS1-003 was elevated in patients in the remitting phase compared with relapsing patients.
      Title: LncRNAs associated with multiple sclerosis expressed in the Th1 cell lineage.
    8. The ulcerative colitis -associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation.
      Title: The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation.
    9. The expression level of LncRNA IFNG-AS1 and IFN-gamma increased significantly in all patient groups with brucellosis compared to healthy subjects. Its effective role in many protective actions, including enhancing the expression of IFN-gamma in the immune response in brucellosis patients, suggest a new molecular interaction response to brucella infection.
      Title: A potential marker in brucellosis, long non coding RNA IFNG-AS1.
    10. These results establish Ifng-as1 as an important regulator of Ifng expression, as a DNA element and transcribed RNA, involved in dynamic and cell state-specific responses to infection.
      Title: The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Other Names

    • IFNG antisense RNA 1 (non-protein coding)
    • LincR-Ifng-3'AS
    • Theiler's murine encephalomyelitis virus persistence candidate gene 1
    • nettoie Salmonella pas Theiler's

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_104124.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294

    2. NR_104125.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294
      Related
      ENST00000538665.6

    3. NR_186227.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294
      Related
      ENST00000718003.1

    4. NR_186228.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294
      Related
      ENST00000717999.1

    5. NR_186229.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294
      Related
      ENST00000718002.1

    6. NR_186230.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294

    7. NR_186231.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005294

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      67989447..68021313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      67968959..68000822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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