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    MADD MAP kinase activating death domain [ Homo sapiens (human) ]

    Gene ID: 8567, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MADDprovided by HGNC
    Official Full Name
    MAP kinase activating death domainprovided by HGNC
    Primary source
    HGNC:HGNC:6766
    See related
    Ensembl:ENSG00000110514 MIM:603584; AllianceGenome:HGNC:6766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DENN; IG20; DEEAH; RabGEF; NEDDISH; RAB3GEP
    Summary
    Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 18.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MADD in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47269188..47330031)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47425958..47486853)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47290739..47351582)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:47236089-47237288 Neighboring gene damage specific DNA binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4694 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:47270641-47270808 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:47280987-47281555 Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene Sharpr-MPRA regulatory region 2100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4695 Neighboring gene Sharpr-MPRA regulatory region 9889 Neighboring gene MADD antisense RNA 1 Neighboring gene myosin binding protein C3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47371915-47372896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47372897-47373877 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:47387327-47387502 Neighboring gene Spi-1 proto-oncogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47395717-47396218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47399745-47400696

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Expression of MADD in lung adenocarcinoma tissues and its effects on proliferation and apoptosis of lung adenocarcinoma A549 cells]. Wei YP, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012 Apr. PMID 22482404
    2. Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder. Abu-Libdeh B, et al. Eur J Hum Genet, 2021 Jun. PMID 33723354, Free PMC Article
    3. Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder. Schneeberger PE, et al. Brain, 2020 Aug 1. PMID 32761064, Free PMC Article
    4. MADD Expression in Lung Adenocarcinoma and its Impact on Proliferation and Apoptosis of Lung Adenocarcinoma Cells. Ye B, et al. Comb Chem High Throughput Screen, 2019. PMID 30947659
    5. Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer. Saini S, et al. Cell Death Dis, 2019 Feb 13. PMID 30760700, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New insights into the clinical and molecular spectrum of the MADD-related neurodevelopmental disorder.
      Title: New insights into the clinical and molecular spectrum of the MADD-related neurodevelopmental disorder.
    2. MADD regulates natural killer cell degranulation through Rab27a activation.
      Title: MADD regulates natural killer cell degranulation through Rab27a activation.
    3. Calloso-adreno-scrotal agenesis associated with biallelic MAPK-activating death domain protein (MADD) variant: Further phenotypic delineation of MADD deficiency.
      Title: Calloso-adreno-scrotal agenesis associated with biallelic MAPK-activating death domain protein (MADD) variant: Further phenotypic delineation of MADD deficiency.
    4. Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder.
      Title: Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder.
    5. GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies.
      Title: GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies.
    6. Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
      Title: Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
    7. Authors show the crucial role of MADD in ATC tumorigenesis and metastasis.
      Title: Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer.
    8. MADD Expression in Lung Adenocarcinoma and its Impact on Proliferation and Apoptosis of Lung Adenocarcinoma Cells
      Title: MADD Expression in Lung Adenocarcinoma and its Impact on Proliferation and Apoptosis of Lung Adenocarcinoma Cells.
    9. The risk of coronary disease and ischemic stroke associated with multiple polymorphisms and haplotypes of MADD and FOLH1 in Han Chinese patients are reported in association with alcohol consumption.
      Title: MADD-FOLH1 Polymorphisms and Their Haplotypes with Serum Lipid Levels and the Risk of Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population.
    10. miR-3151 silencing by DNA methylation protected chronic lymphocytic leukemia cells from apoptosis by over-expression of its direct targets MADD and PIK3R2, constitutive activation of MEK/ERK and PI3K/AKT signaling , and over-expression of MCL1.
      Title: Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Deeah syndrome
    MedGen: C5436579 OMIM: 619004 GeneReviews: Not available
    		Compare labs
    Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia
    MedGen: C5436585 OMIM: 619005 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
    EBI GWAS Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    EBI GWAS Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35600, FLJ36300, KIAA0358

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables death receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rab protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-activating death domain protein
    Names
    Insuloma-Glucagonoma protein 20
    Rab3 GDP/GTP exchange factor
    differentially expressed in normal and neoplastic cells
    insulinoma glucagonoma clone 20
    rab3 GDP/GTP exchange protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029462.2 RefSeqGene

      Range
      5947..65845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135943.2 → NP_001129415.1  MAP kinase-activating death domain protein isoform 9

      See identical proteins and their annotated locations for NP_001129415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, and uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (i) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. NM_001135944.2 → NP_001129416.1  MAP kinase-activating death domain protein isoform 10

      See identical proteins and their annotated locations for NP_001129416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (j) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000378753.3, ENST00000395344.7
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. NM_001376571.1 → NP_001363500.1  MAP kinase-activating death domain protein isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXF1, A0A9L9PYF5
      Related
      ENSP00000516604.1, ENST00000706887.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. NM_001376572.1 → NP_001363501.1  MAP kinase-activating death domain protein isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    5. NM_001376573.1 → NP_001363502.1  MAP kinase-activating death domain protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    6. NM_001376574.1 → NP_001363503.1  MAP kinase-activating death domain protein isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    7. NM_001376575.1 → NP_001363504.1  MAP kinase-activating death domain protein isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    8. NM_001376576.1 → NP_001363505.1  MAP kinase-activating death domain protein isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A0U1RR25, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    9. NM_001376577.1 → NP_001363506.1  MAP kinase-activating death domain protein isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A0U1RR25, A0A9L9PYF5
      Related
      ENSP00000489300.2, ENST00000634938.2
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    10. NM_001376578.1 → NP_001363507.1  MAP kinase-activating death domain protein isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (4) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03132
      Location:717 → 908
      PHA03132; thymidine kinase; Provisional

    11. NM_001376579.1 → NP_001363508.1  MAP kinase-activating death domain protein isoform 77

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    12. NM_001376580.1 → NP_001363509.1  MAP kinase-activating death domain protein isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    13. NM_001376581.1 → NP_001363510.1  MAP kinase-activating death domain protein isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ0, A0A9L9PYF5
      Related
      ENSP00000516602.1, ENST00000706886.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    14. NM_001376582.1 → NP_001363511.1  MAP kinase-activating death domain protein isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    15. NM_001376583.1 → NP_001363512.1  MAP kinase-activating death domain protein isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    16. NM_001376584.1 → NP_001363513.1  MAP kinase-activating death domain protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7931.1
      UniProtKB/TrEMBL
      A0A0A0MRB5, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    17. NM_001376585.1 → NP_001363514.1  MAP kinase-activating death domain protein isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    18. NM_001376586.1 → NP_001363515.1  MAP kinase-activating death domain protein isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    19. NM_001376593.1 → NP_001363522.1  MAP kinase-activating death domain protein isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    20. NM_001376594.1 → NP_001363523.1  MAP kinase-activating death domain protein isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    21. NM_001376595.1 → NP_001363524.1  MAP kinase-activating death domain protein isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXN0, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    22. NM_001376596.1 → NP_001363525.1  MAP kinase-activating death domain protein isoform 76

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    23. NM_001376597.1 → NP_001363526.1  MAP kinase-activating death domain protein isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXN0, A0A9L9PYF5
      Related
      ENSP00000516606.1, ENST00000706889.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    24. NM_001376598.1 → NP_001363527.1  MAP kinase-activating death domain protein isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    25. NM_001376599.1 → NP_001363528.1  MAP kinase-activating death domain protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ3, A0A9L9PYF5
      Related
      ENSP00000516607.1, ENST00000706890.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    26. NM_001376600.1 → NP_001363529.1  MAP kinase-activating death domain protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ3, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    27. NM_001376601.1 → NP_001363530.1  MAP kinase-activating death domain protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ3, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    28. NM_001376602.1 → NP_001363531.1  MAP kinase-activating death domain protein isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    29. NM_001376603.1 → NP_001363532.1  MAP kinase-activating death domain protein isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    30. NM_001376604.1 → NP_001363533.1  MAP kinase-activating death domain protein isoform 75

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    31. NM_001376605.1 → NP_001363534.1  MAP kinase-activating death domain protein isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000516605.1, ENST00000706888.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    32. NM_001376606.1 → NP_001363535.1  MAP kinase-activating death domain protein isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    33. NM_001376607.1 → NP_001363536.1  MAP kinase-activating death domain protein isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    34. NM_001376608.1 → NP_001363537.1  MAP kinase-activating death domain protein isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    35. NM_001376609.1 → NP_001363538.1  MAP kinase-activating death domain protein isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    36. NM_001376610.1 → NP_001363539.1  MAP kinase-activating death domain protein isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    37. NM_001376611.1 → NP_001363540.1  MAP kinase-activating death domain protein isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    38. NM_001376612.1 → NP_001363541.1  MAP kinase-activating death domain protein isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    39. NM_001376613.1 → NP_001363542.1  MAP kinase-activating death domain protein isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    40. NM_001376614.1 → NP_001363543.1  MAP kinase-activating death domain protein isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    41. NM_001376615.1 → NP_001363544.1  MAP kinase-activating death domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44588.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    42. NM_001376616.1 → NP_001363545.1  MAP kinase-activating death domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44588.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    43. NM_001376617.1 → NP_001363546.1  MAP kinase-activating death domain protein isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    44. NM_001376618.1 → NP_001363547.1  MAP kinase-activating death domain protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    45. NM_001376619.1 → NP_001363548.1  MAP kinase-activating death domain protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    46. NM_001376620.1 → NP_001363549.1  MAP kinase-activating death domain protein isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    47. NM_001376621.1 → NP_001363550.1  MAP kinase-activating death domain protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    48. NM_001376622.1 → NP_001363551.1  MAP kinase-activating death domain protein isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    49. NM_001376623.1 → NP_001363552.1  MAP kinase-activating death domain protein isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    50. NM_001376624.1 → NP_001363553.1  MAP kinase-activating death domain protein isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    51. NM_001376625.1 → NP_001363554.1  MAP kinase-activating death domain protein isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    52. NM_001376626.1 → NP_001363555.1  MAP kinase-activating death domain protein isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PY22, A0A9L9PYF5
      Related
      ENSP00000516608.1, ENST00000706891.1
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    53. NM_001376627.1 → NP_001363556.1  MAP kinase-activating death domain protein isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    54. NM_001376628.1 → NP_001363557.1  MAP kinase-activating death domain protein isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    55. NM_001376629.1 → NP_001363558.1  MAP kinase-activating death domain protein isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    56. NM_001376630.1 → NP_001363559.1  MAP kinase-activating death domain protein isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    57. NM_001376631.1 → NP_001363560.1  MAP kinase-activating death domain protein isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (4) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03132
      Location:717 → 908
      PHA03132; thymidine kinase; Provisional

    58. NM_001376632.1 → NP_001363561.1  MAP kinase-activating death domain protein isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    59. NM_001376633.1 → NP_001363562.1  MAP kinase-activating death domain protein isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    60. NM_001376634.1 → NP_001363563.1  MAP kinase-activating death domain protein isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    61. NM_001376635.1 → NP_001363564.1  MAP kinase-activating death domain protein isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    62. NM_001376636.1 → NP_001363565.1  MAP kinase-activating death domain protein isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    63. NM_001376637.1 → NP_001363566.1  MAP kinase-activating death domain protein isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    64. NM_001376638.1 → NP_001363567.1  MAP kinase-activating death domain protein isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    65. NM_001376639.1 → NP_001363568.1  MAP kinase-activating death domain protein isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    66. NM_001376640.1 → NP_001363569.1  MAP kinase-activating death domain protein isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    67. NM_001376641.1 → NP_001363570.1  MAP kinase-activating death domain protein isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    68. NM_001376642.1 → NP_001363571.1  MAP kinase-activating death domain protein isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    69. NM_001376643.1 → NP_001363572.1  MAP kinase-activating death domain protein isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    70. NM_001376644.1 → NP_001363573.1  MAP kinase-activating death domain protein isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    71. NM_001376645.1 → NP_001363574.1  MAP kinase-activating death domain protein isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    72. NM_001376646.1 → NP_001363575.1  MAP kinase-activating death domain protein isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    73. NM_001376647.1 → NP_001363576.1  MAP kinase-activating death domain protein isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PY18, A0A9L9PYF5
      Related
      ENSP00000516603.1, ENST00000526603.6
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    74. NM_001376648.1 → NP_001363577.1  MAP kinase-activating death domain protein isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    75. NM_001376649.1 → NP_001363578.1  MAP kinase-activating death domain protein isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    76. NM_001376650.1 → NP_001363579.1  MAP kinase-activating death domain protein isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    77. NM_001376651.1 → NP_001363580.1  MAP kinase-activating death domain protein isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    78. NM_001376652.1 → NP_001363581.1  MAP kinase-activating death domain protein isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    79. NM_001376653.1 → NP_001363582.1  MAP kinase-activating death domain protein isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    80. NM_001376654.1 → NP_001363583.1  MAP kinase-activating death domain protein isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    81. NM_001376655.1 → NP_001363584.1  MAP kinase-activating death domain protein isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    82. NM_001376656.1 → NP_001363585.1  MAP kinase-activating death domain protein isoform 78

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    83. NM_001376657.1 → NP_001363586.1  MAP kinase-activating death domain protein isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    84. NM_001376658.1 → NP_001363587.1  MAP kinase-activating death domain protein isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    85. NM_001376659.1 → NP_001363588.1  MAP kinase-activating death domain protein isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    86. NM_001376660.1 → NP_001363589.1  MAP kinase-activating death domain protein isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418 → 486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105 → 334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:4 → 30
      uDENN; uDENN domain

    87. NM_001376661.1 → NP_001363590.1  MAP kinase-activating death domain protein isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    88. NM_001376662.1 → NP_001363591.1  MAP kinase-activating death domain protein isoform 73

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    89. NM_001376663.1 → NP_001363592.1  MAP kinase-activating death domain protein isoform 74

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (2) summary
      smart00801
      Location:264 → 332
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:28 → 180
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

    90. NM_003682.4 → NP_003673.3  MAP kinase-activating death domain protein isoform 4

      See identical proteins and their annotated locations for NP_003673.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7930.1
      UniProtKB/Swiss-Prot
      A8K8S7, B5MEE5, D3DQR4, O15065, O15293, Q15732, Q15741, Q8IWD7, Q8WXG3, Q8WXG4, Q8WXG5, Q8WXG6, Q8WZ63
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000310933.4, ENST00000311027.9
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    91. NM_130470.3 → NP_569826.2  MAP kinase-activating death domain protein isoform 1

      See identical proteins and their annotated locations for NP_569826.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has a different exon 1 sequence and lacks exons 16, 21 and 26, as compared to transcript variant 4. The resulting isoform (a) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7931.1
      UniProtKB/TrEMBL
      A0A0A0MRB5, A0A9L9PYF5
      Related
      ENSP00000343902.4, ENST00000342922.8
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    92. NM_130471.3 → NP_569827.2  MAP kinase-activating death domain protein isoform 2

      See identical proteins and their annotated locations for NP_569827.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (b) is missing regions of 43 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44587.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000384204.3, ENST00000407859.7
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    93. NM_130472.3 → NP_569828.2  MAP kinase-activating death domain protein isoform 3

      See identical proteins and their annotated locations for NP_569828.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exons 16, 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (c) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44588.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000385585.1, ENST00000402799.5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    94. NM_130473.3 → NP_569829.2  MAP kinase-activating death domain protein isoform 5

      See identical proteins and their annotated locations for NP_569829.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks exons 21 and 26 as compared to transcript variant 4. The resulting isoform (e) is missing regions of 18 aa and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7932.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000304505.6, ENST00000349238.7
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    95. NM_130474.3 → NP_569830.2  MAP kinase-activating death domain protein isoform 6

      See identical proteins and their annotated locations for NP_569830.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks exons 16, 21, 26, 34, and part of exon 13 but maintains the same reading frame up through exon 33 as compared to transcript variant 4. The resulting isoform (f) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa and has a different carboxyl terminus as compared to isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44590.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000384435.1, ENST00000406482.5
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    96. NM_130475.3 → NP_569831.1  MAP kinase-activating death domain protein isoform 7

      See identical proteins and their annotated locations for NP_569831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has a different exon 1 sequence and lacks exon 34 as compared to transcript variant 4. The resulting isoform (g) is shorter and has a different carboxyl terminus as compared to the isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS41642.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000378745.3, ENST00000395336.7
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    97. NM_130476.3 → NP_569832.2  MAP kinase-activating death domain protein isoform 8

      See identical proteins and their annotated locations for NP_569832.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has a different exon 1 sequence, lacks exons 16, 21 and 26, and uses an alternate in-frame splice site in exon 23, as compared to transcript variant 4. The resulting isoform (h) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44586.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000384287.2, ENST00000402192.6
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RNA

    1. NR_164835.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    2. NR_164836.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    3. NR_164837.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    4. NR_164838.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    5. NR_164839.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    6. NR_164840.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    7. NR_164841.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    8. NR_164842.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      47269188..47330031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      47425958..47486853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WXG6.2 GenPept UniProtKB/Swiss-Prot:Q8WXG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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