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    Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 [ Mus musculus (house mouse) ]

    Gene ID: 18140, updated on 9-Dec-2024

    Summary

    Official Symbol
    Uhrf1provided by MGI
    Official Full Name
    ubiquitin-like, containing PHD and RING finger domains, 1provided by MGI
    Primary source
    MGI:MGI:1338889
    See related
    Ensembl:ENSMUSG00000001228 AllianceGenome:MGI:1338889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Np95; ICBP90; RNF106
    Summary
    Enables several functions, including hemi-methylated DNA-binding activity; histone H3 ubiquitin ligase activity; and identical protein binding activity. Involved in negative regulation of gene expression via chromosomal CpG island methylation and negative regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear matrix; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 54.8), liver E14 (RPKM 50.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Uhrf1 in Genome Data Viewer
    Location:
    17 D; 17 29.26 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56610405..56630486)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56303337..56323486)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8686 Neighboring gene STARR-positive B cell enhancer ABC_E3207 Neighboring gene perilipin 3 Neighboring gene STARR-positive B cell enhancer ABC_E3208 Neighboring gene STARR-positive B cell enhancer ABC_E3209 Neighboring gene arrestin domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E141 Neighboring gene lysine (K)-specific demethylase 4B Neighboring gene STARR-positive B cell enhancer ABC_E8923 Neighboring gene predicted gene, 32715 Neighboring gene protein tyrosine phosphatase receptor type S Neighboring gene microRNA 6977

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hemi-methylated DNA-binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hemi-methylated DNA-binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3 ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables methyl-CpG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase UHRF1
    Names
    RING-type E3 ubiquitin transferase UHRF1
    mUhrf1
    nuclear protein 95
    nuclear zinc finger protein Np95
    ubiquitin-like PHD and RING finger domain-containing protein 1
    ubiquitin-like-containing PHD and RING finger domains protein 1
    NP_001104548.1
    NP_001104549.1
    NP_001104550.1
    NP_001400286.1
    NP_001400287.1
    NP_001400288.1
    NP_001400289.1
    NP_035061.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111078.2NP_001104548.1  E3 ubiquitin-protein ligase UHRF1 isoform A

      See identical proteins and their annotated locations for NP_001104548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode isoform (A).
      Source sequence(s)
      AC026385
      Consensus CDS
      CCDS28903.1
      UniProtKB/Swiss-Prot
      Q3U9D7, Q3U9P2, Q3UI74, Q3UIE6, Q3ULF2, Q3ULQ0, Q8C6F1, Q8VDF2, Q8VIA1, Q9Z1H6
      Related
      ENSMUSP00000108662.3, ENSMUST00000113039.9
      Conserved Domains (6) summary
      cd01797
      Location:178
      NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
      smart00213
      Location:374
      UBQ; Ubiquitin homologues
      cd00162
      Location:713755
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15525
      Location:322368
      PHD_UHRF1_2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein UHRF1 and UHRF2
      pfam02182
      Location:422588
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:129281
      TTD; Tandem tudor domain within UHRF1
    2. NM_001111079.2NP_001104549.1  E3 ubiquitin-protein ligase UHRF1 isoform B

      See identical proteins and their annotated locations for NP_001104549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform B). Variants 3 and 4 encode isoform B.
      Source sequence(s)
      AC026385
      Consensus CDS
      CCDS50151.1
      UniProtKB/Swiss-Prot
      Q8VDF2
      Related
      ENSMUSP00000108661.2, ENSMUST00000113038.8
      Conserved Domains (6) summary
      cd01797
      Location:178
      NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
      smart00213
      Location:374
      UBQ; Ubiquitin homologues
      cd00162
      Location:705747
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15525
      Location:314360
      PHD_UHRF1_2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein UHRF1 and UHRF2
      pfam02182
      Location:414580
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:129281
      TTD; Tandem tudor domain within UHRF1
    3. NM_001111080.2NP_001104550.1  E3 ubiquitin-protein ligase UHRF1 isoform B

      See identical proteins and their annotated locations for NP_001104550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region and differs in the 5' UTR, compared to variant 1, resulting in a shorter protein (isoform B). Variants 3 and 4 encode isoform B.
      Source sequence(s)
      AC026385
      Consensus CDS
      CCDS50151.1
      UniProtKB/Swiss-Prot
      Q8VDF2
      Related
      ENSMUSP00000108658.2, ENSMUST00000113035.8
      Conserved Domains (6) summary
      cd01797
      Location:178
      NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
      smart00213
      Location:374
      UBQ; Ubiquitin homologues
      cd00162
      Location:705747
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15525
      Location:314360
      PHD_UHRF1_2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein UHRF1 and UHRF2
      pfam02182
      Location:414580
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:129281
      TTD; Tandem tudor domain within UHRF1
    4. NM_001413357.1NP_001400286.1  E3 ubiquitin-protein ligase UHRF1 isoform C

      Status: VALIDATED

      Source sequence(s)
      AC026385
    5. NM_001413358.1NP_001400287.1  E3 ubiquitin-protein ligase UHRF1 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC026385
    6. NM_001413359.1NP_001400288.1  E3 ubiquitin-protein ligase UHRF1 isoform E

      Status: VALIDATED

      Source sequence(s)
      AC026385
    7. NM_001413360.1NP_001400289.1  E3 ubiquitin-protein ligase UHRF1 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC026385
    8. NM_010931.4NP_035061.3  E3 ubiquitin-protein ligase UHRF1 isoform A

      See identical proteins and their annotated locations for NP_035061.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 encode isoform (A).
      Source sequence(s)
      AC026385
      Consensus CDS
      CCDS28903.1
      UniProtKB/Swiss-Prot
      Q3U9D7, Q3U9P2, Q3UI74, Q3UIE6, Q3ULF2, Q3ULQ0, Q8C6F1, Q8VDF2, Q8VIA1, Q9Z1H6
      Related
      ENSMUSP00000001258.9, ENSMUST00000001258.15
      Conserved Domains (6) summary
      cd01797
      Location:178
      NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
      smart00213
      Location:374
      UBQ; Ubiquitin homologues
      cd00162
      Location:713755
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15525
      Location:322368
      PHD_UHRF1_2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein UHRF1 and UHRF2
      pfam02182
      Location:422588
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:129281
      TTD; Tandem tudor domain within UHRF1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56610405..56630486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)