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    Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase [ Mus musculus (house mouse) ]

    Gene ID: 13200, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddostprovided by MGI
    Official Full Name
    dolichyl-di-phosphooligosaccharide-protein glycotransferaseprovided by MGI
    Primary source
    MGI:MGI:1194508
    See related
    Ensembl:ENSMUSG00000028757 AllianceGenome:MGI:1194508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in several processes, including T cell activation; protein N-linked glycosylation via asparagine; and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 167.1), ovary adult (RPKM 166.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ddost in Genome Data Viewer
    Location:
    4 D3; 4 70.13 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138032049..138039930)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138304738..138312619)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 5 Neighboring gene predicted gene, 54278 Neighboring gene kinesin family member 17 Neighboring gene STARR-positive B cell enhancer ABC_E8002 Neighboring gene STARR-positive B cell enhancer ABC_E4692 Neighboring gene STARR-seq mESC enhancer starr_11799 Neighboring gene STARR-positive B cell enhancer ABC_E10270 Neighboring gene microRNA 7019 Neighboring gene PTEN induced putative kinase 1 Neighboring gene cytidine deaminase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
    Names
    DDOST 48 kDa subunit
    oligosaccharyl transferase 48 kDa subunit
    NP_031864.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007838.3NP_031864.2  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

      See identical proteins and their annotated locations for NP_031864.2

      Status: VALIDATED

      Source sequence(s)
      BC068132, BU755176
      Consensus CDS
      CCDS18824.1
      UniProtKB/Swiss-Prot
      O54734, Q8C4P7
      UniProtKB/TrEMBL
      Q3UC51
      Related
      ENSMUSP00000030538.5, ENSMUST00000030538.5
      Conserved Domains (1) summary
      pfam03345
      Location:33440
      DDOST_48kD; Oligosaccharyltransferase 48 kDa subunit beta

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138032049..138039930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)