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    Hspa4l heat shock protein 4 like [ Mus musculus (house mouse) ]

    Gene ID: 18415, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hspa4lprovided by MGI
    Official Full Name
    heat shock protein 4 likeprovided by MGI
    Primary source
    MGI:MGI:107422
    See related
    Ensembl:ENSMUSG00000025757 AllianceGenome:MGI:107422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    94kDa; APG-1; Osp94
    Summary
    Predicted to enable ATP binding activity and adenyl-nucleotide exchange factor activity. Predicted to be involved in protein folding and response to unfolded protein. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Orthologous to human HSPA4L (heat shock protein family A (Hsp70) member 4 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 20.6), cerebellum adult (RPKM 14.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hspa4l in Genome Data Viewer
    Location:
    3 B; 3 19.51 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40698664..40750538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40744500..40796103)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:40439532-40439833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:40457146-40457255 Neighboring gene inturned planar cell polarity protein Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene STARR-seq mESC enhancer starr_07472 Neighboring gene STARR-positive B cell enhancer ABC_E9547 Neighboring gene polo like kinase 4 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E1617

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117843

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    heat shock 70 kDa protein 4L
    Names
    heat shock 70-related protein APG-1
    heat shock 70kDa protein 4 like
    osmotic stress protein 94

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410463.1NP_001397392.1  heat shock 70 kDa protein 4L isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC160757
      UniProtKB/Swiss-Prot
      P48722, P97854, Q3TQN2, Q3UNG4, Q8BQD0, Q8CC45, Q91X29
    2. NM_001410464.1NP_001397393.1  heat shock 70 kDa protein 4L isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC160757
      UniProtKB/Swiss-Prot
      P48722, P97854, Q3TQN2, Q3UNG4, Q8BQD0, Q8CC45, Q91X29
    3. NM_001410465.1NP_001397394.1  heat shock 70 kDa protein 4L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160757
    4. NM_011020.4NP_035150.3  heat shock 70 kDa protein 4L isoform 1

      See identical proteins and their annotated locations for NP_035150.3

      Status: VALIDATED

      Source sequence(s)
      AC160757
      Consensus CDS
      CCDS17327.1
      UniProtKB/Swiss-Prot
      P48722, P97854, Q3TQN2, Q3UNG4, Q8BQD0, Q8CC45, Q91X29
      Related
      ENSMUSP00000145468.2, ENSMUST00000204702.3
      Conserved Domains (1) summary
      cd11738
      Location:2384
      HSPA4L_NBD; Nucleotide-binding domain of HSPA4L

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      40698664..40750538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)