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    Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 [ Mus musculus (house mouse) ]

    Gene ID: 66335, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp6v1c1provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit C1provided by MGI
    Primary source
    MGI:MGI:1913585
    See related
    Ensembl:ENSMUSG00000022295 AllianceGenome:MGI:1913585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700025B18Rik
    Summary
    Enables proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Located in plasma membrane. Part of proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 58.2), frontal lobe adult (RPKM 53.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp6v1c1 in Genome Data Viewer
    Location:
    15 B3.1; 15 15.18 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38662096..38692688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (38661904..38692444)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310043O21 gene Neighboring gene predicted gene, 41309 Neighboring gene siah E3 ubiquitin protein ligase 1, pseudogene 2 Neighboring gene predicted gene, 29697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:38532013-38532196 Neighboring gene RIKEN cDNA 1100001I12 gene Neighboring gene STARR-positive B cell enhancer ABC_E1172 Neighboring gene predicted gene, 53877 Neighboring gene STARR-seq mESC enhancer starr_38465 Neighboring gene predicted gene, 45924 Neighboring gene predicted gene, 53229

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extrinsic component of synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proton-transporting V-type ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proton-transporting V-type ATPase, V1 domain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase subunit C 1
    Names
    ATPase, H+ transporting, V1 subunit C
    V-ATPase subunit C 1
    vacuolar proton pump subunit C 1
    NP_079770.2
    XP_036015431.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025494.3NP_079770.2  V-type proton ATPase subunit C 1

      See identical proteins and their annotated locations for NP_079770.2

      Status: VALIDATED

      Source sequence(s)
      AK151237, BB869068, BQ746792
      Consensus CDS
      CCDS27439.1
      UniProtKB/Swiss-Prot
      Q91Z42, Q9Z1G3
      UniProtKB/TrEMBL
      Q3TG21
      Related
      ENSMUSP00000022904.7, ENSMUST00000022904.8
      Conserved Domains (1) summary
      pfam03223
      Location:5370
      V-ATPase_C; V-ATPase subunit C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      38662096..38692688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159538.1XP_036015431.1  V-type proton ATPase subunit C 1 isoform X1