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    Elf4 E74 like ETS transcription factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 56501, updated on 9-Dec-2024

    Summary

    Official Symbol
    Elf4provided by MGI
    Official Full Name
    E74 like ETS transcription factor 4provided by MGI
    Primary source
    MGI:MGI:1928377
    See related
    Ensembl:ENSMUSG00000031103 AllianceGenome:MGI:1928377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mef; Gm9907
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including lymphocyte proliferation; negative regulation of cytokine production; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human ELF4 (E74 like ETS transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 29.1), spleen adult (RPKM 20.4) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Elf4 in Genome Data Viewer
    Location:
    X A5; X 25.67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47499926..47552009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48411049..48463132, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530027J09 gene Neighboring gene UTP14A small subunit processome component Neighboring gene STARR-positive B cell enhancer mm9_chrX:45637714-45638015 Neighboring gene STARR-seq mESC enhancer starr_47113 Neighboring gene STARR-seq mESC enhancer starr_47114 Neighboring gene STARR-seq mESC enhancer starr_47116 Neighboring gene BCL6 co-repressor-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45782874-45783027 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45786781-45786934 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene RAB33A, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129343, MGC129361

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in NK T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in natural killer cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ETS-related transcription factor Elf-4
    Names
    E74-like factor 4 (ets domain transcription factor)
    E74-like factor 4; myeloid elf-1-like factor; myeloid elf-1 like factor
    myeloid elf-1-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381876.1NP_001368805.1  ETS-related transcription factor Elf-4

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL844594
      UniProtKB/Swiss-Prot
      B1AY67, Q9Z2U4
      UniProtKB/TrEMBL
      Q32MF0, Q3U2M4
      Related
      ENSMUSP00000110608.2, ENSMUST00000114958.8
      Conserved Domains (2) summary
      pfam00178
      Location:209289
      Ets; Ets-domain
      pfam12310
      Location:2103
      Elf-1_N; Transcription factor protein N terminal
    2. NM_019680.2NP_062654.2  ETS-related transcription factor Elf-4

      See identical proteins and their annotated locations for NP_062654.2

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL844594
      Consensus CDS
      CCDS30108.1
      UniProtKB/Swiss-Prot
      B1AY67, Q9Z2U4
      UniProtKB/TrEMBL
      Q32MF0, Q3U2M4
      Related
      ENSMUSP00000033429.3, ENSMUST00000033429.9
      Conserved Domains (2) summary
      pfam00178
      Location:209289
      Ets; Ets-domain
      pfam12310
      Location:2103
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      47499926..47552009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541527.1XP_006541590.1  ETS-related transcription factor Elf-4 isoform X1

      See identical proteins and their annotated locations for XP_006541590.1

      UniProtKB/Swiss-Prot
      B1AY67, Q9Z2U4
      UniProtKB/TrEMBL
      Q32MF0, Q3U2M4
      Conserved Domains (2) summary
      pfam00178
      Location:209289
      Ets; Ets-domain
      pfam12310
      Location:2103
      Elf-1_N; Transcription factor protein N terminal