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    Chrm3 cholinergic receptor, muscarinic 3, cardiac [ Mus musculus (house mouse) ]

    Gene ID: 12671, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chrm3provided by MGI
    Official Full Name
    cholinergic receptor, muscarinic 3, cardiacprovided by MGI
    Primary source
    MGI:MGI:88398
    See related
    Ensembl:ENSMUSG00000046159 AllianceGenome:MGI:88398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M3; M3R; Chrm-3
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 8.4), bladder adult (RPKM 7.2) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chrm3 in Genome Data Viewer
    Location:
    13 A1; 13 3.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (9925522..10411131, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (9875486..10361062, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33625 Neighboring gene predicted gene, 36423 Neighboring gene zinc finger, MYND domain containing 11 Neighboring gene STARR-positive B cell enhancer ABC_E4050 Neighboring gene STARR-positive B cell enhancer ABC_E1454 Neighboring gene STARR-seq mESC enhancer starr_33627 Neighboring gene predicted gene, 40665 Neighboring gene STARR-seq mESC enhancer starr_33628 Neighboring gene STARR-seq mESC enhancer starr_33629 Neighboring gene STARR-seq mESC enhancer starr_33630 Neighboring gene STARR-seq mESC enhancer starr_33631 Neighboring gene STARR-seq mESC enhancer starr_33632 Neighboring gene predicted gene, 26861 Neighboring gene STARR-seq mESC enhancer starr_33633 Neighboring gene STARR-seq mESC enhancer starr_33634 Neighboring gene predicted gene, 36525 Neighboring gene STARR-seq mESC enhancer starr_33635 Neighboring gene STARR-seq mESC enhancer starr_33636 Neighboring gene predicted gene, 40666

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled acetylcholine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled acetylcholine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled acetylcholine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables quaternary ammonium group binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables quaternary ammonium group binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ligand-gated ion channel signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of heart rate by acetylcholine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of heart rate by acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within saliva secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M3
    Names
    AChR M3
    mm3 mAChR
    muscarinic acetylcholine receptor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428369.1NP_001415298.1  muscarinic acetylcholine receptor M3

      Status: VALIDATED

      Source sequence(s)
      AC122288, AC124429, AC146596, AC158115
      UniProtKB/Swiss-Prot
      Q64055, Q9ERZ3
      UniProtKB/TrEMBL
      Q542R4
    2. NM_001428370.1NP_001415299.1  muscarinic acetylcholine receptor M3

      Status: VALIDATED

      Source sequence(s)
      AC122288, AC124429, AC140445, AC146596, AC158115
      UniProtKB/Swiss-Prot
      Q64055, Q9ERZ3
      UniProtKB/TrEMBL
      Q542R4
    3. NM_033269.5NP_150372.1  muscarinic acetylcholine receptor M3

      See identical proteins and their annotated locations for NP_150372.1

      Status: VALIDATED

      Source sequence(s)
      AC122288, AC124429, AC146596, AC158115
      Consensus CDS
      CCDS26238.1
      UniProtKB/Swiss-Prot
      Q64055, Q9ERZ3
      UniProtKB/TrEMBL
      Q542R4
      Related
      ENSMUSP00000140131.2, ENSMUST00000187510.7
      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486511
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      9925522..10411131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516468.5XP_006516531.1  muscarinic acetylcholine receptor M3 isoform X1

      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486511
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily