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    Semg1 semenogelin 1 [ Mus musculus (house mouse) ]

    Gene ID: 53878, updated on 9-Dec-2024

    Summary

    Official Symbol
    Semg1provided by MGI
    Official Full Name
    semenogelin 1provided by MGI
    Primary source
    MGI:MGI:1858275
    See related
    Ensembl:ENSMUSG00000040132 AllianceGenome:MGI:1858275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Svs2; SvsII
    Summary
    Predicted to enable protease binding activity and zinc ion binding activity. Acts upstream of or within fertilization and sperm capacitation. Located in acrosomal vesicle. Is expressed in alimentary system; bladder; and male reproductive gland or organ. Orthologous to human SEMG1 (semenogelin 1) and SEMG2 (semenogelin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Semg1 in Genome Data Viewer
    Location:
    2 H3; 2 84.82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164077849..164080261, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164235929..164238341, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 15A Neighboring gene WAP four-disulfide core domain 15B Neighboring gene seminal vesicle secretory protein 3B Neighboring gene seminal vesicle secretory protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC130221

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within fertilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sperm capacitation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    semenogelin I
    Names
    semenoclotin
    seminal vesicle protein, secretion 2
    seminal vesicle secretory protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017390.4NP_059086.3  semenogelin I precursor

      See identical proteins and their annotated locations for NP_059086.3

      Status: VALIDATED

      Source sequence(s)
      AK035204, AK144285, BB871464, DV056729
      Consensus CDS
      CCDS17027.1
      UniProtKB/TrEMBL
      Q3UN62, Q8BS30
      Related
      ENSMUSP00000042389.3, ENSMUST00000044953.3
      Conserved Domains (1) summary
      pfam05474
      Location:588
      Semenogelin; Semenogelin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164077849..164080261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)