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    G6pc2 glucose-6-phosphatase, catalytic, 2 [ Mus musculus (house mouse) ]

    Gene ID: 14378, updated on 27-Nov-2024

    Summary

    Official Symbol
    G6pc2provided by MGI
    Official Full Name
    glucose-6-phosphatase, catalytic, 2provided by MGI
    Primary source
    MGI:MGI:1277193
    See related
    Ensembl:ENSMUSG00000005232 AllianceGenome:MGI:1277193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IGRP; G6pc-rs
    Summary
    This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See G6pc2 in Genome Data Viewer
    Location:
    2 C2; 2 39.66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69041417..69058337)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69211073..69227993)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04727 Neighboring gene predicted gene, 39840 Neighboring gene nitric oxide synthase trafficker Neighboring gene STARR-positive B cell enhancer ABC_E412 Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_04729 Neighboring gene ATP-binding cassette, sub-family B member 11 Neighboring gene STARR-seq mESC enhancer starr_04731 Neighboring gene STARR-seq mESC enhancer starr_04732 Neighboring gene predicted gene, 36393 Neighboring gene dehydrogenase/reductase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucose-6-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucose-6-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucose-6-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glucose-6-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    glucose-6-phosphatase 2
    Names
    G-6-Pase 2
    glucose-6-phosphatase, catalytic, related sequence
    islet-specific glucose-6-phosphatase catalytic subunit-related protein
    NP_001276785.1
    NP_001276786.1
    NP_067306.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289856.1NP_001276785.1  glucose-6-phosphatase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK148465, BP758187, BQ557220
      UniProtKB/Swiss-Prot
      Q9Z186
      Conserved Domains (1) summary
      cl00474
      Location:1162
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
    2. NM_001289857.1NP_001276786.1  glucose-6-phosphatase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate exon in the coding region resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK148450, BP758187
      Consensus CDS
      CCDS71066.1
      UniProtKB/Swiss-Prot
      Q9Z186
      Related
      ENSMUSP00000107936.3, ENSMUST00000112317.3
      Conserved Domains (1) summary
      cl00474
      Location:38138
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
    3. NM_021331.4NP_067306.1  glucose-6-phosphatase 2 isoform 1

      See identical proteins and their annotated locations for NP_067306.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK148450, AK148465, BP758187
      Consensus CDS
      CCDS16089.1
      UniProtKB/Swiss-Prot
      A2AUN2, Q2M2M7, Q9Z186
      Related
      ENSMUSP00000005364.6, ENSMUST00000005364.12
      Conserved Domains (2) summary
      COG0671
      Location:36193
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03381
      Location:38278
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69041417..69058337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)