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    Arl6ip1 ADP-ribosylation factor-like 6 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 54208, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arl6ip1provided by MGI
    Official Full Name
    ADP-ribosylation factor-like 6 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1858943
    See related
    Ensembl:ENSMUSG00000030654 AllianceGenome:MGI:1858943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIP-6; ARMER; Aip-1; Arl6ip; mKIAA0069
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of L-glutamate import across plasma membrane. Acts upstream of or within cotranslational protein targeting to membrane. Located in cytosol; endoplasmic reticulum; and membrane. Part of Sec61 translocon complex. Is expressed in several structures, including central nervous system; genitourinary system; retina; and stomach. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 117.1), CNS E11.5 (RPKM 89.0) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arl6ip1 in Genome Data Viewer
    Location:
    7 F1; 7 63.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (117718113..117728848, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118118890..118129625, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34878 Neighboring gene STARR-positive B cell enhancer ABC_E1357 Neighboring gene ribosomal protein S15A Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125272620-125272803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125273191-125273420 Neighboring gene SMG1 nonsense mediated mRNA decay associated PI3K related kinase Neighboring gene predicted gene, 25683 Neighboring gene STARR-seq mESC enhancer starr_20001 Neighboring gene predicted gene, 40454

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum tubular network formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum tubular network formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum tubular network membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum tubular network membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of L-glutamate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of endoplasmic reticulum tubular network organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Sec61 translocon complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum tubular network IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 6-interacting protein 1
    Names
    ADP-ribosylation-like factor 6 interacting protein
    ARL-6-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019419.2NP_062292.1  ADP-ribosylation factor-like protein 6-interacting protein 1

      See identical proteins and their annotated locations for NP_062292.1

      Status: VALIDATED

      Source sequence(s)
      AC131788, AK152565, BC046792
      Consensus CDS
      CCDS21769.1
      UniProtKB/Swiss-Prot
      Q9JKW0, Q9JLI9, Q9WUG3
      UniProtKB/TrEMBL
      Q3TIC7, Q80ZW9, Q8C1Y9
      Related
      ENSMUSP00000032888.8, ENSMUST00000032888.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      117718113..117728848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)