U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 54393, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gabbr1provided by MGI
    Official Full Name
    gamma-aminobutyric acid type B receptor subunit 1provided by MGI
    Primary source
    MGI:MGI:1860139
    See related
    Ensembl:ENSMUSG00000024462 AllianceGenome:MGI:1860139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GABAB1; GABAbR1; bM573K1.1
    Summary
    Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Located in cytoplasm; postsynaptic membrane; and presynaptic membrane. Part of G protein-coupled receptor dimeric complex. Is active in GABA-ergic synapse and Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 73.7), frontal lobe adult (RPKM 72.2) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gabbr1 in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37356888..37385197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (37045966..37074305)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42498 Neighboring gene STARR-seq mESC enhancer starr_42499 Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene zinc finger protein 57 Neighboring gene STARR-seq mESC enhancer starr_42503 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene STARR-seq mESC enhancer starr_42504 Neighboring gene STARR-seq mESC enhancer starr_42506 Neighboring gene predicted gene, 41579 Neighboring gene olfactory receptor family 2 subfamily H member 2 Neighboring gene olfactory receptor family 2 subfamily H member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to G protein-coupled GABA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled GABA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to G protein-coupled GABA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled GABA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential EXP
    Inferred from Experiment
    more info
    PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables extracellular matrix protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gamma-aminobutyric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gamma-aminobutyric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron-glial cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron-glial cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, GABAergic NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled GABA receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of G protein-coupled receptor dimeric complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of G protein-coupled receptor heterodimeric complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of G protein-coupled receptor heterodimeric complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of GABA receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gamma-aminobutyric acid type B receptor subunit 1
    Names
    GABA-B receptor 1
    GABA-B-R1
    GABA-BR1
    GABA-BR1b receptor
    bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)
    gamma-aminobutyric acid (GABA) B receptor, 1
    gb1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413996.1NP_001400925.1  gamma-aminobutyric acid type B receptor subunit 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116130, CR974567
    2. NM_001413997.1NP_001400926.1  gamma-aminobutyric acid type B receptor subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116130, CR974567
      UniProtKB/TrEMBL
      Q8CAF8
    3. NM_019439.4NP_062312.3  gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_062312.3

      Status: VALIDATED

      Source sequence(s)
      AC116130, CR974567
      Consensus CDS
      CCDS37616.1
      UniProtKB/Swiss-Prot
      Q6PGJ2, Q9WU48, Q9WV15, Q9WV16, Q9WV17, Q9WV18
      Related
      ENSMUSP00000025338.10, ENSMUST00000025338.16
      Conserved Domains (5) summary
      cd06366
      Location:170562
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:602856
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam00084
      Location:106156
      Sushi; Sushi repeat (SCR repeat)
      pfam01094
      Location:186542
      ANF_receptor; Receptor family ligand binding region
      pfam10211
      Location:884926
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37356888..37385197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249909.1XP_030105769.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      Q8CAF8
      Conserved Domains (3) summary
      cd15291
      Location:413685
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam10211
      Location:708750
      Ax_dynein_light; Axonemal dynein light chain
      cd06366
      Location:2393
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    2. XM_030249908.1XP_030105768.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      Q8CAF8
      Related
      ENSMUSP00000134268.2, ENSMUST00000172792.8
      Conserved Domains (3) summary
      cd15291
      Location:473745
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam10211
      Location:768810
      Ax_dynein_light; Axonemal dynein light chain
      cd06366
      Location:54453
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

    RNA

    1. XR_001782091.3 RNA Sequence

      Related
      ENSMUST00000173823.8