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    Pou2f1 POU domain, class 2, transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 18986, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pou2f1provided by MGI
    Official Full Name
    POU domain, class 2, transcription factor 1provided by MGI
    Primary source
    MGI:MGI:101898
    See related
    Ensembl:ENSMUSG00000026565 AllianceGenome:MGI:101898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oct1; Otf1; NF-A1; Oct-1; Otf-1; 2810482H01Rik
    Summary
    Enables chromatin binding activity and sequence-specific DNA binding activity. Acts upstream of or within lens induction in camera-type eye; olfactory placode formation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cerebellum; embryo ectoderm; genitourinary system; lung; and sensory organ. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 4.4), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pou2f1 in Genome Data Viewer
    Location:
    1 H2.3; 1 73.21 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165692719..165830318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165865150..166002749, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD247 antigen Neighboring gene predicted gene, 23402 Neighboring gene STARR-seq mESC enhancer starr_02912 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167775596-167775783 Neighboring gene predicted gene, 32999 Neighboring gene STARR-seq mESC enhancer starr_02913 Neighboring gene STARR-positive B cell enhancer ABC_E3324 Neighboring gene STARR-positive B cell enhancer ABC_E9065 Neighboring gene STARR-positive B cell enhancer ABC_E2581 Neighboring gene STARR-positive B cell enhancer ABC_E4375 Neighboring gene STARR-positive B cell enhancer ABC_E4376 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167878460-167878761 Neighboring gene heat shock protein 8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2582 Neighboring gene STARR-seq mESC enhancer starr_02914 Neighboring gene STARR-positive B cell enhancer ABC_E798 Neighboring gene STARR-seq mESC enhancer starr_02915 Neighboring gene STARR-seq mESC enhancer starr_02916 Neighboring gene predicted gene, 53642 Neighboring gene transcription elongation factor B polypeptide 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    POU domain, class 2, transcription factor 1
    Names
    octamer-binding protein 1
    octamer-binding transcription factor 1
    ubiquitous transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368808.1NP_001355737.1  POU domain, class 2, transcription factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093371
      UniProtKB/Swiss-Prot
      P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
      UniProtKB/TrEMBL
      A0A0A0MQE0
      Conserved Domains (2) summary
      smart00352
      Location:281355
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:385439
      Homeobox; Homeobox domain
    2. NM_011137.3NP_035267.2  POU domain, class 2, transcription factor 1 isoform A

      See identical proteins and their annotated locations for NP_035267.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (A).
      Source sequence(s)
      AC093371, AK028237
      Consensus CDS
      CCDS35760.1
      UniProtKB/TrEMBL
      A0A0A0MQE0, A0A0R4J1Z4
      Related
      ENSMUSP00000124738.2, ENSMUST00000160260.9
      Conserved Domains (2) summary
      smart00352
      Location:304378
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:408461
      Homeobox; Homeobox domain
    3. NM_198932.3NP_945150.2  POU domain, class 2, transcription factor 1 isoform Z

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform Z, which is shorter than isoform A.
      Source sequence(s)
      AC093371
      Consensus CDS
      CCDS48430.1
      UniProtKB/TrEMBL
      E9Q6Z8, I1E4X2
      Related
      ENSMUSP00000125444.2, ENSMUST00000160908.8
      Conserved Domains (2) summary
      smart00352
      Location:304378
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:408461
      Homeobox; Homeobox domain
    4. NM_198933.3NP_945151.2  POU domain, class 2, transcription factor 1 isoform L

      See identical proteins and their annotated locations for NP_945151.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' terminal exon and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform L, which is shorter and has a distinct N-terminus, compared to isoform A.
      Source sequence(s)
      AC093371
      Consensus CDS
      CCDS15444.1
      UniProtKB/TrEMBL
      A0A0A0MQE0
      Related
      ENSMUSP00000064000.6, ENSMUST00000069609.12
      Conserved Domains (2) summary
      smart00352
      Location:293367
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:397450
      Homeobox; Homeobox domain
    5. NM_198934.3NP_945152.2  POU domain, class 2, transcription factor 1 isoform B

      See identical proteins and their annotated locations for NP_945152.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' terminal exon, compared to variant 1. It encodes isoform B, which is shorter and has a distinct N-terminus, compared to isoform A.
      Source sequence(s)
      AC093371
      Consensus CDS
      CCDS35761.1
      UniProtKB/TrEMBL
      A0A0A0MQE0, F8VQL7
      Related
      ENSMUSP00000107056.3, ENSMUST00000111427.9
      Conserved Domains (2) summary
      smart00352
      Location:293367
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:397450
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165692719..165830318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252286.1XP_030108146.1  POU domain, class 2, transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
      UniProtKB/TrEMBL
      A0A0A0MQE0
      Conserved Domains (2) summary
      smart00352
      Location:281355
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:385439
      Homeobox; Homeobox domain
    2. XM_006496704.4XP_006496767.1  POU domain, class 2, transcription factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006496767.1

      UniProtKB/Swiss-Prot
      P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
      UniProtKB/TrEMBL
      A0A0A0MQE0
      Conserved Domains (2) summary
      smart00352
      Location:281355
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:385439
      Homeobox; Homeobox domain
    3. XM_030252287.2XP_030108147.1  POU domain, class 2, transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A0A0MQE0
      Related
      ENSMUSP00000107057.5, ENSMUST00000111429.11
      Conserved Domains (2) summary
      smart00352
      Location:281355
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:385439
      Homeobox; Homeobox domain
    4. XM_036162785.1XP_036018678.1  POU domain, class 2, transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
      UniProtKB/TrEMBL
      A0A0A0MQE0
      Conserved Domains (2) summary
      smart00352
      Location:281355
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:385439
      Homeobox; Homeobox domain
    5. XM_017319360.3XP_017174849.1  POU domain, class 2, transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A0A0MQE0
      Conserved Domains (2) summary
      smart00352
      Location:281355
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:385439
      Homeobox; Homeobox domain

    RNA

    1. XR_373598.2 RNA Sequence