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    Ceacam1 CEA cell adhesion molecule 1 [ Mus musculus (house mouse) ]

    Gene ID: 26365, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ceacam1provided by MGI
    Official Full Name
    CEA cell adhesion molecule 1provided by MGI
    Primary source
    MGI:MGI:1347245
    See related
    Ensembl:ENSMUSG00000074272 AllianceGenome:MGI:1347245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a
    Summary
    Enables Toll-like receptor binding activity; granulocyte colony-stimulating factor receptor binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; and negative regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of T cell proliferation; negative regulation of bone resorption; and negative regulation of osteoclast differentiation. Located in ciliary membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and skeleton. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 419.7), large intestine adult (RPKM 308.1) and 3 other tissues See more
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    Genomic context

    See Ceacam1 in Genome Data Viewer
    Location:
    7 A3; 7 13.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25161127..25177072, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25461702..25477647, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene STARR-seq mESC enhancer starr_18304 Neighboring gene RELT tumor necrosis factor receptor pseudogene Neighboring gene chaperonin containing Tcp1, subunit 4 (delta) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2818 Neighboring gene predicted gene, 38967 Neighboring gene CEA cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18305 Neighboring gene STARR-seq mESC enhancer starr_18306

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GPI anchor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Toll-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables bile acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables granulocyte colony-stimulating factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in common myeloid progenitor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in granulocyte colony-stimulating factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytotoxic T cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of homophilic cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of homophilic cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of homophilic cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of T cell receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transforming growth factor beta ligand-receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell adhesion molecule CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1
    Names
    BGP-1
    CEA-related cell adhesion molecule 1
    MHV-R
    biliary glycoprotein 1
    biliary glycoprotein D
    carcinoembryonic antigen 1
    carcinoembryonic antigen 7
    hepatitis virus (MHV-4) susceptibility
    hepatitis virus receptor
    murine hepatitis virus receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039185.1NP_001034274.1  cell adhesion molecule CEACAM1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001034274.1

      Status: VALIDATED

      Source sequence(s)
      AAHY01060000, AB236328, M77196
      Consensus CDS
      CCDS20984.1
      UniProtKB/Swiss-Prot
      P31809, Q61350, Q61353
      UniProtKB/TrEMBL
      Q925P3
      Related
      ENSMUSP00000096266.2, ENSMUST00000098669.8
      Conserved Domains (6) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:340401
      IGc2; Immunoglobulin C-2 Type
      cd12841
      Location:416452
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146235
      Ig; Immunoglobulin domain
    2. NM_001039186.1NP_001034275.1  cell adhesion molecule CEACAM1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001034275.1

      Status: VALIDATED

      Source sequence(s)
      AAHY01060000, M77196
      Consensus CDS
      CCDS39839.1
      UniProtKB/TrEMBL
      Q61351
      Related
      ENSMUSP00000096263.3, ENSMUST00000098666.9
      Conserved Domains (6) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:340401
      IGc2; Immunoglobulin C-2 Type
      cd12841
      Location:416452
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146235
      Ig; Immunoglobulin domain
    3. NM_001039187.1NP_001034276.1  cell adhesion molecule CEACAM1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001034276.1

      Status: VALIDATED

      Source sequence(s)
      AAHY01060000, AB236329
      Consensus CDS
      CCDS85244.1
      UniProtKB/TrEMBL
      Q3LFS6, Q3LFS8
      Related
      ENSMUSP00000146066.2, ENSMUST00000206687.2
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd12841
      Location:236272
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      smart00410
      Location:153226
      IG_like; Immunoglobulin like
      cl11960
      Location:142232
      Ig; Immunoglobulin domain
    4. NM_011926.2NP_036056.2  cell adhesion molecule CEACAM1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_036056.2

      Status: VALIDATED

      Source sequence(s)
      AAHY01060000, AB236328
      Consensus CDS
      CCDS20985.1
      UniProtKB/TrEMBL
      Q3LFS9, Q61354
      Related
      ENSMUSP00000096265.2, ENSMUST00000098668.3
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:160221
      IGc2; Immunoglobulin C-2 Type
      cd12841
      Location:236272
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      smart00410
      Location:153226
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25161127..25177072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242604.1XP_030098464.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

      UniProtKB/TrEMBL
      Q3LFS5, Q61351
      Related
      ENSMUSP00000145590.2, ENSMUST00000206676.2
      Conserved Domains (4) summary
      smart00408
      Location:340401
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13895
      Location:242315
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146235
      Ig; Immunoglobulin domain