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    Mpzl1 myelin protein zero-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 68481, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mpzl1provided by MGI
    Official Full Name
    myelin protein zero-like 1provided by MGI
    Primary source
    MGI:MGI:1915731
    See related
    Ensembl:ENSMUSG00000026566 AllianceGenome:MGI:1915731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PZR; 1110007A10Rik
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human MPZL1 (myelin protein zero like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 77.0), limb E14.5 (RPKM 61.2) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mpzl1 in Genome Data Viewer
    Location:
    1 H2.3; 1 72.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165419745..165462144, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165592176..165634541, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 10 Neighboring gene predicted gene, 51751 Neighboring gene predicted gene, 51750 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167509733-167510033 Neighboring gene STARR-positive B cell enhancer ABC_E11103 Neighboring gene STARR-positive B cell enhancer ABC_E4372 Neighboring gene STARR-positive B cell enhancer ABC_E324 Neighboring gene STARR-positive B cell enhancer ABC_E1570 Neighboring gene nuclear encoded tRNA proline 2 (anticodon AGG) Neighboring gene nuclear encoded tRNA proline 2 (anticodon CGG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    myelin protein zero-like protein 1
    Names
    protein zero-related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001880.2NP_001001880.1  myelin protein zero-like protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001001880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BB871672, BC072563, CX210059
      Consensus CDS
      CCDS35758.1
      UniProtKB/TrEMBL
      A0A0A6YW22, A0A0R4J0V2
      Related
      ENSMUSP00000070343.8, ENSMUST00000068705.13
      Conserved Domains (2) summary
      cd05715
      Location:39154
      Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
      smart00410
      Location:43154
      IG_like; Immunoglobulin like
    2. NM_001083897.1NP_001077366.1  myelin protein zero-like protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001077366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK169385, BB871672, CX210059
      Consensus CDS
      CCDS35757.1
      UniProtKB/Swiss-Prot
      Q2VW02, Q3TEW6, Q6GQX5
      UniProtKB/TrEMBL
      A0A0A6YWA2
      Related
      ENSMUSP00000107062.3, ENSMUST00000111435.9
      Conserved Domains (2) summary
      cd00096
      Location:3842
      Ig; Ig strand A [structural motif]
      cl11960
      Location:38154
      Ig; Immunoglobulin domain
    3. NM_001347128.1NP_001334057.1  myelin protein zero-like protein 1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC102776
      Consensus CDS
      CCDS83623.1
      UniProtKB/TrEMBL
      A0A0A6YXW1
      Related
      ENSMUSP00000142164.2, ENSMUST00000194437.6
      Conserved Domains (1) summary
      cl11960
      Location:3986
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165419745..165462144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004934160.1 RNA Sequence