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    Mpc2 mitochondrial pyruvate carrier 2 [ Mus musculus (house mouse) ]

    Gene ID: 70456, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mpc2provided by MGI
    Official Full Name
    mitochondrial pyruvate carrier 2provided by MGI
    Primary source
    MGI:MGI:1917706
    See related
    Ensembl:ENSMUSG00000026568 AllianceGenome:MGI:1917706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brp44; ESTM43; 0610006C01Rik; 2010002I07Rik; 2610205H19Rik
    Summary
    Enables pyruvate transmembrane transporter activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Acts upstream of or within mitochondrial pyruvate transmembrane transport and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including brain; early conceptus; heart; and liver. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 132.5), testis adult (RPKM 127.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mpc2 in Genome Data Viewer
    Location:
    1 H2.3; 1 72.8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165288829..165308787)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165461260..165481218)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene adenylate cyclase 10 Neighboring gene zinc finger protein 758 pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 1_1625.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyruvate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to pyruvate transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial pyruvate carrier 2
    Names
    brain protein 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027430.3NP_081706.1  mitochondrial pyruvate carrier 2

      See identical proteins and their annotated locations for NP_081706.1

      Status: VALIDATED

      Source sequence(s)
      AC162789
      Consensus CDS
      CCDS15442.1
      UniProtKB/Swiss-Prot
      Q3UA44, Q9D023
      Related
      ENSMUSP00000027853.6, ENSMUST00000027853.6
      Conserved Domains (1) summary
      pfam03650
      Location:33122
      MPC; Uncharacterized protein family (UPF0041)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165288829..165308787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)