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    Zkscan8 zinc finger with KRAB and SCAN domains 8 [ Mus musculus (house mouse) ]

    Gene ID: 93681, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zkscan8provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 8provided by MGI
    Primary source
    MGI:MGI:1913815
    See related
    Ensembl:ENSMUSG00000063894 AllianceGenome:MGI:1913815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LD5-1; Zfp192; 2510038J07Rik; D430019P06Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human ZKSCAN8 (zinc finger with KRAB and SCAN domains 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.0), whole brain E14.5 (RPKM 3.6) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Zkscan8 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21697391..21715284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21513221..21531114, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5373 Neighboring gene zinc finger protein 389 Neighboring gene predicted gene, 32724 Neighboring gene olfactory receptor family 1 subfamily F member 12 Neighboring gene olfactory receptor family 2 subfamily B member 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General protein information

    Preferred Names
    zinc finger protein with KRAB and SCAN domains 8
    Names
    zinc finger protein 192

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001251833.1NP_001238762.1  zinc finger protein with KRAB and SCAN domains 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the CDS, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL589742, BC150775, BY333359
      Consensus CDS
      CCDS88420.1
      UniProtKB/TrEMBL
      A0A286YCX3
      Conserved Domains (3) summary
      smart00431
      Location:48158
      SCAN; leucine rich region
      COG5048
      Location:250502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374394
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001251834.1NP_001238763.1  zinc finger protein with KRAB and SCAN domains 8 isoform 3

      See identical proteins and their annotated locations for NP_001238763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BY333359, CX566615
      Consensus CDS
      CCDS56871.1
      UniProtKB/TrEMBL
      Q78WV9
      Related
      ENSMUSP00000106107.3, ENSMUST00000110481.3
      Conserved Domains (1) summary
      pfam02023
      Location:48133
      SCAN; SCAN domain
    3. NM_139141.4NP_631880.2  zinc finger protein with KRAB and SCAN domains 8 isoform 1

      See identical proteins and their annotated locations for NP_631880.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK032718, AL589742, BY333359
      Consensus CDS
      CCDS26278.1
      UniProtKB/TrEMBL
      Q8BSL0
      Related
      ENSMUSP00000040248.6, ENSMUST00000045228.12
      Conserved Domains (4) summary
      smart00431
      Location:48158
      SCAN; leucine rich region
      cd07765
      Location:233268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:322574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446466
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21697391..21715284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247476.2XP_030103336.1  zinc finger protein with KRAB and SCAN domains 8 isoform X2

      UniProtKB/TrEMBL
      A0A286YCX3
      Related
      ENSMUSP00000153171.2, ENSMUST00000224362.2
      Conserved Domains (3) summary
      smart00431
      Location:48158
      SCAN; leucine rich region
      COG5048
      Location:250502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374394
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_030247475.1XP_030103335.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

      UniProtKB/TrEMBL
      Q8BSL0
      Conserved Domains (4) summary
      smart00431
      Location:48158
      SCAN; leucine rich region
      cd07765
      Location:233268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:322574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446466
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_030247477.1XP_030103337.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

      Conserved Domains (3) summary
      cd07765
      Location:5792
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:146398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:270290
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_030247474.2XP_030103334.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

      UniProtKB/TrEMBL
      Q8BSL0
      Conserved Domains (4) summary
      smart00431
      Location:48158
      SCAN; leucine rich region
      cd07765
      Location:233268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:322574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446466
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_036158230.1XP_036014123.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

      Conserved Domains (3) summary
      cd07765
      Location:5792
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:146398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:270290
      ZF_C2H2; C2H2 Zn finger [structural motif]