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    Suv39h2 suppressor of variegation 3-9 2 [ Mus musculus (house mouse) ]

    Gene ID: 64707, updated on 9-Dec-2024

    Summary

    Official Symbol
    Suv39h2provided by MGI
    Official Full Name
    suppressor of variegation 3-9 2provided by MGI
    Primary source
    MGI:MGI:1890396
    See related
    Ensembl:ENSMUSG00000026646 AllianceGenome:MGI:1890396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT1B; D2Ertd544e; 4930507K23Rik; D030054H19Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone H3K9me2 methyltransferase activity. Involved in circadian rhythm; male meiotic nuclear division; and negative regulation of macromolecule biosynthetic process. Located in heterochromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and limb. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.6), placenta adult (RPKM 3.1) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Suv39h2 in Genome Data Viewer
    Location:
    2 A1; 2 1.95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3456852..3476085, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3455815..3474986, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39750 Neighboring gene STARR-positive B cell enhancer ABC_E5880 Neighboring gene meiosis expressed gene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:3341062-3341360 Neighboring gene DNA cross-link repair 1C Neighboring gene STARR-seq mESC enhancer starr_03514 Neighboring gene STARR-seq mESC enhancer starr_03515 Neighboring gene predicted gene, 54099 Neighboring gene heat shock protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E272 Neighboring gene Myb/SANT DNA binding domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K9 methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables histone H3K9 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K9 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K9 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9me2 methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epigenetic programming in the zygotic pronuclei ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male meiotic nuclear division IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SUV39H2
    Names
    H3-K9-HMTase 2
    Suv39h histone methyltransferase
    histone H3-K9 methyltransferase 2
    su(var)3-9 homolog 2
    suppressor of variegation 3-9 homolog 2
    NP_073561.2
    XP_036018338.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022724.4NP_073561.2  histone-lysine N-methyltransferase SUV39H2

      See identical proteins and their annotated locations for NP_073561.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AK083457, AL732620, CX227854
      Consensus CDS
      CCDS15652.1
      UniProtKB/Swiss-Prot
      Q8BNK2, Q9CUK3, Q9EQQ0, Q9JLP7
      UniProtKB/TrEMBL
      A0A0R4J074
      Related
      ENSMUSP00000027956.3, ENSMUST00000027956.9
      Conserved Domains (3) summary
      smart00317
      Location:317446
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00385
      Location:119164
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam05033
      Location:221309
      Pre-SET; Pre-SET motif

    RNA

    1. NR_027509.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and therefore is not thought to encode a protein.
      Source sequence(s)
      AK083457, AL732620, BY752501, CX227854

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3456852..3476085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162445.1XP_036018338.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

      Conserved Domains (1) summary
      cd10532
      Location:15257
      SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins